국가 R&D 과제 조회
과제고유번호 1345290581 당해연도 연구기간 2018-03-01 ~ 2019-02-28
과제년도 2018 총 연구기간 2016-03-01 ~ 2020-08-31
주관부처명 교육부 연구기관명 경북대학교
사업명 BK21플러스사업(R&D)
과제명 한글 멀티 오믹스 융합 기술 기반 혁신 신약 연구 전문인력 양성 사업팀
영문 Multi-Omics Convergence Technology-based Creative Drug Research Training Team
연구개발단계 기타 지역 대구
6T분류 BT • 보건의료관련응용 • 의과학·의공학기술
과학기술표준분류 의약품/의약품개발기술 / 저분자의약품

총 연구비
연도 정부 연구비(원) 민간 연구비(원) 사업예산
2018 116,370,500 0 116,370,500
관련 논문(76) 관련 특허(1) 관련 장비(0) 관련 보고서(0)

Development of a simultaneous LC-MS/MS method to predict in vivo drug-drug interaction in mice
성과년도
2018
성과 고유번호
JNL-2018-00110222668
학술지명
ARCHIVES OF PHARMACAL RESEARCH
ISSN
0253-6269
PKC alpha-LSD1-NF-kappa B-Signaling Cascade Is Crucial for Epigenetic Control of the Inflammatory Response
성과년도
2018
성과 고유번호
JNL-2018-00110222654
학술지명
MOLECULAR CELL
ISSN
1097-2765
Palladium nanoparticle-decorated 2-D graphene oxide for effective photodynamic and photothermal therapy of prostate solid tumors
성과년도
2018
성과 고유번호
JNL-2018-00110222646
학술지명
COLLOIDS AND SURFACES B-BIOINTERFACES
ISSN
0927-7765
Inhibitory Effects of Sulforaphane on Polyphosphate-mediated Septic Responses
성과년도
2018
성과 고유번호
JNL-2018-00110222648
학술지명
INTERNATIONAL JOURNAL OF PHARMACOLOGY
ISSN
1811-7775
Simultaneous Determination of Five Cytochrome P450 Probe Substrates and Their Metabolites and Organic Anion Transporting Polypeptide Probe Substrate in Human Plasma Using Liquid Chromatography-Tandem ...
성과년도
2018
성과 고유번호
JNL-2018-00110222639
학술지명
PHARMACEUTICS
ISSN
1999-4923
Decursinol Angelate Inhibits LPS-Induced Macrophage Polarization through Modulation of the NF kappa B and MAPK Signaling Pathways
성과년도
2018
성과 고유번호
JNL-2018-00110222647
학술지명
MOLECULES
ISSN
1420-3049
Inhibitory Effect of Sulforaphane on Secretory Group IIA Phospholipase A(2)
성과년도
2018
성과 고유번호
JNL-2018-00110222652
학술지명
INTERNATIONAL JOURNAL OF PHARMACOLOGY
ISSN
1811-7775
Emerging role of RUNX3 in the regulation of tumor microenvironment
성과년도
2018
성과 고유번호
JNL-2018-00110222645
학술지명
BMB REPORTS
ISSN
1976-6696
Validation of a Multiresidue Analysis Method for 379 Pesticides in Human Serum Using Liquid Chromatography-Tandem Mass Spectrometry
성과년도
2018
성과 고유번호
JNL-2018-00110222635
학술지명
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
ISSN
0021-8561
Design, synthesis, and biological evaluation of a series of resorcinol-based N-benzyl benzamide derivatives as potent Hsp90 inhibitors
성과년도
2018
성과 고유번호
JNL-2018-00110222631
학술지명
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
ISSN
0223-5234
Clusterin deficiency induces lipid accumulation and tissue damage in kidney
성과년도
2018
성과 고유번호
JNL-2018-00110222636
학술지명
JOURNAL OF ENDOCRINOLOGY
ISSN
0022-0795
Cooperative interactions between seed-borne bacterial and air-borne fungal pathogens on rice
성과년도
2018
성과 고유번호
JNL-2018-00110222630
학술지명
NATURE COMMUNICATIONS
ISSN
2041-1723
Cudratricusxanthone A attenuates sepsis-induced liver injury via SIRT1 signaling
성과년도
2018
성과 고유번호
JNL-2018-00110222659
학술지명
JOURNAL OF CELLULAR PHYSIOLOGY
ISSN
0021-9541
DC23, a Triazolothione Resorcinol Analogue, Is Extensively Metabolized to Glucuronide Conjugates in Human Liver Microsomes
성과년도
2018
성과 고유번호
JNL-2018-00110222634
학술지명
Mass Spectrometry Letters
ISSN
2233-4203
The inhibitory potential of Broussochalcone A for the human cytochrome P450 2J2 isoform and its anti-cancer effects via FOXO3 activation
성과년도
2018
성과 고유번호
JNL-2018-00110222633
학술지명
PHYTOMEDICINE
ISSN
0944-7113
Inhibitory Effect of Pelargonidin on Secretory Group IIA Phospholipase A2
성과년도
2018
성과 고유번호
JNL-2018-00110222660
학술지명
NATURAL PRODUCT COMMUNICATIONS
ISSN
1934-578X
Characterization of CYPs and UGTs Involved in Human Liver Microsomal Metabolism of Osthenol
성과년도
2018
성과 고유번호
JNL-2018-00110222676
학술지명
PHARMACEUTICS
ISSN
1999-4923
Non-targeted metabolomics-guided sildenafil metabolism study in human liver microsomes
성과년도
2018
성과 고유번호
JNL-2018-00110222663
학술지명
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
ISSN
1570-0232
Investigation of nonalcoholic fatty liver disease-induced drug metabolism by comparative global toxicoproteomics
성과년도
2018
성과 고유번호
JNL-2018-00110222670
학술지명
TOXICOLOGY AND APPLIED PHARMACOLOGY
ISSN
0041-008X
Quantitative Proteomic Analysis of Changes Related to Age and Calorie Restriction in Rat Liver Tissue
성과년도
2018
성과 고유번호
JNL-2018-00110222666
학술지명
PROTEOMICS
ISSN
1615-9853
The Ancient Phosphatidylinositol 3-Kinase Signaling System Is a Master Regulator of Energy and Carbon Metabolism in Algae
성과년도
2018
성과 고유번호
JNL-2018-00110222640
학술지명
PLANT PHYSIOLOGY
ISSN
0032-0889
Metabolic regulation of macrophages in tumor microenvironment
성과년도
2018
성과 고유번호
JNL-2018-00110222649
학술지명
CURRENT OPINION IN HEMATOLOGY
ISSN
1065-6251
Sulforaphane Suppresses Sepsis-Mediated Renal Functions in Cecal Ligation and Puncture Mouse Model
성과년도
2018
성과 고유번호
JNL-2018-00110222658
학술지명
NATURAL PRODUCT COMMUNICATIONS
ISSN
1934-578X
Isolation, Synthesis, and Antisepsis Effects of a C-Methylcoumarinochromone Isolated from Abronia nano Cell Culture
성과년도
2018
성과 고유번호
JNL-2018-00110222657
학술지명
JOURNAL OF NATURAL PRODUCTS
ISSN
0163-3864
Phytosphingosine Increases Biosynthesis of Phytoceramide by Uniquely Stimulating the Expression of Dihydroceramide C4-desaturase (DES2) in Cultured Human Keratinocytes
성과년도
2018
성과 고유번호
JNL-2018-00110222644
학술지명
LIPIDS
ISSN
0024-4201
Protective effects of zingerone on lipopolysaccharide-induced hepatic failure through the modulation of inflammatory pathways
성과년도
2018
성과 고유번호
JNL-2018-00110222653
학술지명
CHEMICO-BIOLOGICAL INTERACTIONS
ISSN
0009-2797
A Pharmacometabolomic Approach to Predict Response to Metformin in Early-Phase Type 2 Diabetes Mellitus Patients
성과년도
2018
성과 고유번호
JNL-2018-00110222638
학술지명
MOLECULES
ISSN
1420-3049
Suppressive Effects of Zingerone on Polyphosphate-Mediated Vascular Inflammatory Responses
성과년도
2018
성과 고유번호
JNL-2018-00110222651
학술지명
INTERNATIONAL JOURNAL OF PHARMACOLOGY
ISSN
1811-7775
Suppressive effects of zingerone on TGFBIp-mediated septic responses
성과년도
2018
성과 고유번호
JNL-2018-00110222655
학술지명
ARCHIVES OF PHARMACAL RESEARCH
ISSN
0253-6269
Protective Effects of Pelargonidin on Lipopolysaccharide-induced Hepatic Failure
성과년도
2018
성과 고유번호
JNL-2018-00110222650
학술지명
NATURAL PRODUCT COMMUNICATIONS
ISSN
1934-578X
Impaired permeability and antimicrobial barriers in type 2 diabetes skin are linked to increased serum levels of advanced glycation end-product
성과년도
2018
성과 고유번호
JNL-2018-00110222641
학술지명
EXPERIMENTAL DERMATOLOGY
ISSN
0906-6705
Exploring the Metabolism of Loxoprofen in Liver Microsomes: The Role of Cytochrome P450 and UDP-Glucuronosyltransferase in Its Biotransformation
성과년도
2018
성과 고유번호
JNL-2018-00110222674
학술지명
PHARMACEUTICS
ISSN
1999-4923
Metabolomics-assisted metabolite profiling of itraconazole in human liver preparations
성과년도
2018
성과 고유번호
JNL-2018-00110222667
학술지명
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
ISSN
1570-0232
Renal protective effects of aspalathin and nothofagin from rooibos (Aspalathus linearis) in a mouse model of sepsis
성과년도
2018
성과 고유번호
JNL-2018-00110222662
학술지명
PHARMACOLOGICAL REPORTS
ISSN
1734-1140
Macrophagic Stabilin-1 Restored Disruption of Vascular Integrity Caused by Sepsis
성과년도
2018
성과 고유번호
JNL-2018-00110222661
학술지명
THROMBOSIS AND HAEMOSTASIS
ISSN
0340-6245
Selective Inhibitory Effect of Osthenol on Human Cytochrome 2C8
성과년도
2018
성과 고유번호
JNL-2018-00110222669
학술지명
BULLETIN OF THE KOREAN CHEMICAL SOCIETY
ISSN
0253-2964
First profiling of lysine crotonylation of myofilament proteins and ribosomal proteins in zebrafish embryos
성과년도
2018
성과 고유번호
JNL-2018-00110222664
학술지명
SCIENTIFIC REPORTS
ISSN
2045-2322
Comparative Secretome Profiling and Mutant Protein Identification in Metastatic Prostate Cancer Cells by Quantitative Mass Spectrometry-based Proteomics
성과년도
2018
성과 고유번호
JNL-2018-00110222672
학술지명
CANCER GENOMICS & PROTEOMICS
ISSN
1109-6535
Selective inhibition of CYP2C8 by fisetin and its methylated metabolite, geraldol, in human liver microsomes
성과년도
2018
성과 고유번호
JNL-2018-00110222665
학술지명
DRUG METABOLISM AND PHARMACOKINETICS
ISSN
1347-4367
Terfenadone is a strong inhibitor of CYP2J2 present in the human liver and intestinal microsomes
성과년도
2018
성과 고유번호
JNL-2018-00110222637
학술지명
DRUG METABOLISM AND PHARMACOKINETICS
ISSN
1347-4367
A Comprehensive In Vivo and In Vitro Assessment of the Drug Interaction Potential of Red Ginseng
성과년도
2018
성과 고유번호
JNL-2018-00110222642
학술지명
CLINICAL THERAPEUTICS
ISSN
0149-2918
Metabolomic and lipidomic analysis of the effect of pioglitazone on hepatic steatosis in a rat model of obese Type 2 diabetes
성과년도
2018
성과 고유번호
JNL-2018-00110222643
학술지명
BRITISH JOURNAL OF PHARMACOLOGY
ISSN
0007-1188
Testican-1, as a novel diagnosis of sepsis
성과년도
2018
성과 고유번호
JNL-2018-00110222656
학술지명
JOURNAL OF CELLULAR BIOCHEMISTRY
ISSN
0730-2312
LRRK2 G2019S Induces Anxiety/Depression-like Behavior before the Onset of Motor Dysfunction with 5-HT1A Receptor Upregulation in Mice
성과년도
2018
성과 고유번호
JNL-2018-00110222632
학술지명
JOURNAL OF NEUROSCIENCE
ISSN
0270-6474
Inhibitory Effect of Pelargonidin on Secretory Group IIA Phospholipase A2
성과년도
2018
성과 고유번호
JNL-2018-00110222660
학술지명
NATURAL PRODUCT COMMUNICATIONS
ISSN
1934-578X
Renal protective effects of aspalathin and nothofagin from rooibos (Aspalathus linearis) in a mouse model of sepsis
성과년도
2018
성과 고유번호
JNL-2018-00110222662
학술지명
PHARMACOLOGICAL REPORTS
ISSN
1734-1140
Phytosphingosine Increases Biosynthesis of Phytoceramide by Uniquely Stimulating the Expression of Dihydroceramide C4-desaturase (DES2) in Cultured Human Keratinocytes
성과년도
2018
성과 고유번호
JNL-2018-00110222644
학술지명
LIPIDS
ISSN
0024-4201
Macrophagic Stabilin-1 Restored Disruption of Vascular Integrity Caused by Sepsis
성과년도
2018
성과 고유번호
JNL-2018-00110222661
학술지명
THROMBOSIS AND HAEMOSTASIS
ISSN
0340-6245
Simultaneous Determination of Five Cytochrome P450 Probe Substrates and Their Metabolites and Organic Anion Transporting Polypeptide Probe Substrate in Human Plasma Using Liquid Chromatography-Tandem Mass Spectrometry
성과년도
2018
성과 고유번호
JNL-2018-00110222639
학술지명
PHARMACEUTICS
ISSN
1999-4923
Terfenadone is a strong inhibitor of CYP2J2 present in the human liver and intestinal microsomes
성과년도
2018
성과 고유번호
JNL-2018-00110222637
학술지명
DRUG METABOLISM AND PHARMACOKINETICS
ISSN
1347-4367
Exploring the Metabolism of Loxoprofen in Liver Microsomes: The Role of Cytochrome P450 and UDP-Glucuronosyltransferase in Its Biotransformation
성과년도
2018
성과 고유번호
JNL-2018-00110222674
학술지명
PHARMACEUTICS
ISSN
1999-4923
Characterization of CYPs and UGTs Involved in Human Liver Microsomal Metabolism of Osthenol
성과년도
2018
성과 고유번호
JNL-2018-00110222676
학술지명
PHARMACEUTICS
ISSN
1999-4923
Decursinol Angelate Inhibits LPS-Induced Macrophage Polarization through Modulation of the NF kappa B and MAPK Signaling Pathways
성과년도
2018
성과 고유번호
JNL-2018-00110222647
학술지명
MOLECULES
ISSN
1420-3049
A Comprehensive In Vivo and In Vitro Assessment of the Drug Interaction Potential of Red Ginseng
성과년도
2018
성과 고유번호
JNL-2018-00110222642
학술지명
CLINICAL THERAPEUTICS
ISSN
0149-2918
Metabolomic and lipidomic analysis of the effect of pioglitazone on hepatic steatosis in a rat model of obese Type 2 diabetes
성과년도
2018
성과 고유번호
JNL-2018-00110222643
학술지명
BRITISH JOURNAL OF PHARMACOLOGY
ISSN
0007-1188
A Pharmacometabolomic Approach to Predict Response to Metformin in Early-Phase Type 2 Diabetes Mellitus Patients
성과년도
2018
성과 고유번호
JNL-2018-00110222638
학술지명
MOLECULES
ISSN
1420-3049
The Ancient Phosphatidylinositol 3-Kinase Signaling System Is a Master Regulator of Energy and Carbon Metabolism in Algae
성과년도
2018
성과 고유번호
JNL-2018-00110222640
학술지명
PLANT PHYSIOLOGY
ISSN
0032-0889
Palladium nanoparticle-decorated 2-D graphene oxide for effective photodynamic and photothermal therapy of prostate solid tumors
성과년도
2018
성과 고유번호
JNL-2018-00110222646
학술지명
COLLOIDS AND SURFACES B-BIOINTERFACES
ISSN
0927-7765
Suppressive effects of zingerone on TGFBIp-mediated septic responses
성과년도
2018
성과 고유번호
JNL-2018-00110222655
학술지명
ARCHIVES OF PHARMACAL RESEARCH
ISSN
0253-6269
Validation of a Multiresidue Analysis Method for 379 Pesticides in Human Serum Using Liquid Chromatography-Tandem Mass Spectrometry
성과년도
2018
성과 고유번호
JNL-2018-00110222635
학술지명
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
ISSN
0021-8561
Quantitative Proteomic Analysis of Changes Related to Age and Calorie Restriction in Rat Liver Tissue
성과년도
2018
성과 고유번호
JNL-2018-00110222666
학술지명
PROTEOMICS
ISSN
1615-9853
Cudratricusxanthone A attenuates sepsis-induced liver injury via SIRT1 signaling
성과년도
2018
성과 고유번호
JNL-2018-00110222659
학술지명
JOURNAL OF CELLULAR PHYSIOLOGY
ISSN
0021-9541
Inhibitory Effects of Sulforaphane on Polyphosphate-mediated Septic Responses
성과년도
2018
성과 고유번호
JNL-2018-00110222648
학술지명
INTERNATIONAL JOURNAL OF PHARMACOLOGY
ISSN
1811-7775
Non-targeted metabolomics-guided sildenafil metabolism study in human liver microsomes
성과년도
2018
성과 고유번호
JNL-2018-00110222663
학술지명
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
ISSN
1570-0232
The inhibitory potential of Broussochalcone A for the human cytochrome P450 2J2 isoform and its anti-cancer effects via FOXO3 activation
성과년도
2018
성과 고유번호
JNL-2018-00110222633
학술지명
PHYTOMEDICINE
ISSN
0944-7113
Selective inhibition of CYP2C8 by fisetin and its methylated metabolite, geraldol, in human liver microsomes
성과년도
2018
성과 고유번호
JNL-2018-00110222665
학술지명
DRUG METABOLISM AND PHARMACOKINETICS
ISSN
1347-4367
Impaired permeability and antimicrobial barriers in type 2 diabetes skin are linked to increased serum levels of advanced glycation end-product
성과년도
2018
성과 고유번호
JNL-2018-00110222641
학술지명
EXPERIMENTAL DERMATOLOGY
ISSN
0906-6705
Suppressive Effects of Zingerone on Polyphosphate-Mediated Vascular Inflammatory Responses
성과년도
2018
성과 고유번호
JNL-2018-00110222651
학술지명
INTERNATIONAL JOURNAL OF PHARMACOLOGY
ISSN
1811-7775
Selective Inhibitory Effect of Osthenol on Human Cytochrome 2C8
성과년도
2018
성과 고유번호
JNL-2018-00110222669
학술지명
BULLETIN OF THE KOREAN CHEMICAL SOCIETY
ISSN
0253-2964
Protective effects of zingerone on lipopolysaccharide-induced hepatic failure through the modulation of inflammatory pathways
성과년도
2018
성과 고유번호
JNL-2018-00110222653
학술지명
CHEMICO-BIOLOGICAL INTERACTIONS
ISSN
0009-2797
Protective Effects of Pelargonidin on Lipopolysaccharide-induced Hepatic Failure
성과년도
2018
성과 고유번호
JNL-2018-00110222650
학술지명
NATURAL PRODUCT COMMUNICATIONS
ISSN
1934-578X
Metabolic regulation of macrophages in tumor microenvironment
성과년도
2018
성과 고유번호
JNL-2018-00110222649
학술지명
CURRENT OPINION IN HEMATOLOGY
ISSN
1065-6251
Inhibitory Effect of Sulforaphane on Secretory Group IIA Phospholipase A(2)
성과년도
2018
성과 고유번호
JNL-2018-00110222652
학술지명
INTERNATIONAL JOURNAL OF PHARMACOLOGY
ISSN
1811-7775
Sulforaphane Suppresses Sepsis-Mediated Renal Functions in Cecal Ligation and Puncture Mouse Model
성과년도
2018
성과 고유번호
JNL-2018-00110222658
학술지명
NATURAL PRODUCT COMMUNICATIONS
ISSN
1934-578X
Testican-1, as a novel diagnosis of sepsis
성과년도
2018
성과 고유번호
JNL-2018-00110222656
학술지명
JOURNAL OF CELLULAR BIOCHEMISTRY
ISSN
0730-2312
Isolation, Synthesis, and Antisepsis Effects of a C-Methylcoumarinochromone Isolated from Abronia nano Cell Culture
성과년도
2018
성과 고유번호
JNL-2018-00110222657
학술지명
JOURNAL OF NATURAL PRODUCTS
ISSN
0163-3864