출원등록명	2,5,6,7-tetrasubstituted thiazolo[4,5-b]pyridine derivatives and use thereof
산업재산권 구분	특허	특허구분	등록
출원등록번호	9932355	출원등록자	경북대학교산학협력단
출원등록국가	미국	IPC 코드	C07D513/04
성과년도	2018	NTIS 성과고유번호	PTR-2018-00210237790

멀티 오믹스 융합 기술 기반 혁신 신약 연구 전문인력 양성 사업팀(Multi-Omics Convergence Technology-based Creative Drug Research Training Team) 과제년도 2018 과제번호 1345290581 연구기관 경북대학교 연구기간 2018-03-01~2019-02-28

Development of a simultaneous LC-MS/MS method to predict in vivo drug-drug interaction in mice 성과년도 2018 성과 고유번호 JNL-2018-00110222668 학술지명 ARCHIVES OF PHARMACAL RESEARCH ISSN 0253-6269

PKC alpha-LSD1-NF-kappa B-Signaling Cascade Is Crucial for Epigenetic Control of the Inflammatory Response 성과년도 2018 성과 고유번호 JNL-2018-00110222654 학술지명 MOLECULAR CELL ISSN 1097-2765

Palladium nanoparticle-decorated 2-D graphene oxide for effective photodynamic and photothermal therapy of prostate solid tumors 성과년도 2018 성과 고유번호 JNL-2018-00110222646 학술지명 COLLOIDS AND SURFACES B-BIOINTERFACES ISSN 0927-7765

Inhibitory Effects of Sulforaphane on Polyphosphate-mediated Septic Responses 성과년도 2018 성과 고유번호 JNL-2018-00110222648 학술지명 INTERNATIONAL JOURNAL OF PHARMACOLOGY ISSN 1811-7775

Simultaneous Determination of Five Cytochrome P450 Probe Substrates and Their Metabolites and Organic Anion Transporting Polypeptide Probe Substrate in Human Plasma Using Liquid Chromatography-Tandem ... 성과년도 2018 성과 고유번호 JNL-2018-00110222639 학술지명 PHARMACEUTICS ISSN 1999-4923

Decursinol Angelate Inhibits LPS-Induced Macrophage Polarization through Modulation of the NF kappa B and MAPK Signaling Pathways 성과년도 2018 성과 고유번호 JNL-2018-00110222647 학술지명 MOLECULES ISSN 1420-3049

Inhibitory Effect of Sulforaphane on Secretory Group IIA Phospholipase A(2) 성과년도 2018 성과 고유번호 JNL-2018-00110222652 학술지명 INTERNATIONAL JOURNAL OF PHARMACOLOGY ISSN 1811-7775

Emerging role of RUNX3 in the regulation of tumor microenvironment 성과년도 2018 성과 고유번호 JNL-2018-00110222645 학술지명 BMB REPORTS ISSN 1976-6696

Validation of a Multiresidue Analysis Method for 379 Pesticides in Human Serum Using Liquid Chromatography-Tandem Mass Spectrometry 성과년도 2018 성과 고유번호 JNL-2018-00110222635 학술지명 JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY ISSN 0021-8561

Design, synthesis, and biological evaluation of a series of resorcinol-based N-benzyl benzamide derivatives as potent Hsp90 inhibitors 성과년도 2018 성과 고유번호 JNL-2018-00110222631 학술지명 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY ISSN 0223-5234

Clusterin deficiency induces lipid accumulation and tissue damage in kidney 성과년도 2018 성과 고유번호 JNL-2018-00110222636 학술지명 JOURNAL OF ENDOCRINOLOGY ISSN 0022-0795

Cooperative interactions between seed-borne bacterial and air-borne fungal pathogens on rice 성과년도 2018 성과 고유번호 JNL-2018-00110222630 학술지명 NATURE COMMUNICATIONS ISSN 2041-1723

Cudratricusxanthone A attenuates sepsis-induced liver injury via SIRT1 signaling 성과년도 2018 성과 고유번호 JNL-2018-00110222659 학술지명 JOURNAL OF CELLULAR PHYSIOLOGY ISSN 0021-9541

DC23, a Triazolothione Resorcinol Analogue, Is Extensively Metabolized to Glucuronide Conjugates in Human Liver Microsomes 성과년도 2018 성과 고유번호 JNL-2018-00110222634 학술지명 Mass Spectrometry Letters ISSN 2233-4203

The inhibitory potential of Broussochalcone A for the human cytochrome P450 2J2 isoform and its anti-cancer effects via FOXO3 activation 성과년도 2018 성과 고유번호 JNL-2018-00110222633 학술지명 PHYTOMEDICINE ISSN 0944-7113

Inhibitory Effect of Pelargonidin on Secretory Group IIA Phospholipase A2 성과년도 2018 성과 고유번호 JNL-2018-00110222660 학술지명 NATURAL PRODUCT COMMUNICATIONS ISSN 1934-578X

Characterization of CYPs and UGTs Involved in Human Liver Microsomal Metabolism of Osthenol 성과년도 2018 성과 고유번호 JNL-2018-00110222676 학술지명 PHARMACEUTICS ISSN 1999-4923

Non-targeted metabolomics-guided sildenafil metabolism study in human liver microsomes 성과년도 2018 성과 고유번호 JNL-2018-00110222663 학술지명 JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES ISSN 1570-0232

Investigation of nonalcoholic fatty liver disease-induced drug metabolism by comparative global toxicoproteomics 성과년도 2018 성과 고유번호 JNL-2018-00110222670 학술지명 TOXICOLOGY AND APPLIED PHARMACOLOGY ISSN 0041-008X

Quantitative Proteomic Analysis of Changes Related to Age and Calorie Restriction in Rat Liver Tissue 성과년도 2018 성과 고유번호 JNL-2018-00110222666 학술지명 PROTEOMICS ISSN 1615-9853

The Ancient Phosphatidylinositol 3-Kinase Signaling System Is a Master Regulator of Energy and Carbon Metabolism in Algae 성과년도 2018 성과 고유번호 JNL-2018-00110222640 학술지명 PLANT PHYSIOLOGY ISSN 0032-0889

Metabolic regulation of macrophages in tumor microenvironment 성과년도 2018 성과 고유번호 JNL-2018-00110222649 학술지명 CURRENT OPINION IN HEMATOLOGY ISSN 1065-6251

Sulforaphane Suppresses Sepsis-Mediated Renal Functions in Cecal Ligation and Puncture Mouse Model 성과년도 2018 성과 고유번호 JNL-2018-00110222658 학술지명 NATURAL PRODUCT COMMUNICATIONS ISSN 1934-578X

Isolation, Synthesis, and Antisepsis Effects of a C-Methylcoumarinochromone Isolated from Abronia nano Cell Culture 성과년도 2018 성과 고유번호 JNL-2018-00110222657 학술지명 JOURNAL OF NATURAL PRODUCTS ISSN 0163-3864

Phytosphingosine Increases Biosynthesis of Phytoceramide by Uniquely Stimulating the Expression of Dihydroceramide C4-desaturase (DES2) in Cultured Human Keratinocytes 성과년도 2018 성과 고유번호 JNL-2018-00110222644 학술지명 LIPIDS ISSN 0024-4201

Protective effects of zingerone on lipopolysaccharide-induced hepatic failure through the modulation of inflammatory pathways 성과년도 2018 성과 고유번호 JNL-2018-00110222653 학술지명 CHEMICO-BIOLOGICAL INTERACTIONS ISSN 0009-2797

A Pharmacometabolomic Approach to Predict Response to Metformin in Early-Phase Type 2 Diabetes Mellitus Patients 성과년도 2018 성과 고유번호 JNL-2018-00110222638 학술지명 MOLECULES ISSN 1420-3049

Suppressive Effects of Zingerone on Polyphosphate-Mediated Vascular Inflammatory Responses 성과년도 2018 성과 고유번호 JNL-2018-00110222651 학술지명 INTERNATIONAL JOURNAL OF PHARMACOLOGY ISSN 1811-7775

Suppressive effects of zingerone on TGFBIp-mediated septic responses 성과년도 2018 성과 고유번호 JNL-2018-00110222655 학술지명 ARCHIVES OF PHARMACAL RESEARCH ISSN 0253-6269

Protective Effects of Pelargonidin on Lipopolysaccharide-induced Hepatic Failure 성과년도 2018 성과 고유번호 JNL-2018-00110222650 학술지명 NATURAL PRODUCT COMMUNICATIONS ISSN 1934-578X

Impaired permeability and antimicrobial barriers in type 2 diabetes skin are linked to increased serum levels of advanced glycation end-product 성과년도 2018 성과 고유번호 JNL-2018-00110222641 학술지명 EXPERIMENTAL DERMATOLOGY ISSN 0906-6705

Exploring the Metabolism of Loxoprofen in Liver Microsomes: The Role of Cytochrome P450 and UDP-Glucuronosyltransferase in Its Biotransformation 성과년도 2018 성과 고유번호 JNL-2018-00110222674 학술지명 PHARMACEUTICS ISSN 1999-4923

Metabolomics-assisted metabolite profiling of itraconazole in human liver preparations 성과년도 2018 성과 고유번호 JNL-2018-00110222667 학술지명 JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES ISSN 1570-0232

Renal protective effects of aspalathin and nothofagin from rooibos (Aspalathus linearis) in a mouse model of sepsis 성과년도 2018 성과 고유번호 JNL-2018-00110222662 학술지명 PHARMACOLOGICAL REPORTS ISSN 1734-1140

Macrophagic Stabilin-1 Restored Disruption of Vascular Integrity Caused by Sepsis 성과년도 2018 성과 고유번호 JNL-2018-00110222661 학술지명 THROMBOSIS AND HAEMOSTASIS ISSN 0340-6245

Selective Inhibitory Effect of Osthenol on Human Cytochrome 2C8 성과년도 2018 성과 고유번호 JNL-2018-00110222669 학술지명 BULLETIN OF THE KOREAN CHEMICAL SOCIETY ISSN 0253-2964

First profiling of lysine crotonylation of myofilament proteins and ribosomal proteins in zebrafish embryos 성과년도 2018 성과 고유번호 JNL-2018-00110222664 학술지명 SCIENTIFIC REPORTS ISSN 2045-2322

Comparative Secretome Profiling and Mutant Protein Identification in Metastatic Prostate Cancer Cells by Quantitative Mass Spectrometry-based Proteomics 성과년도 2018 성과 고유번호 JNL-2018-00110222672 학술지명 CANCER GENOMICS & PROTEOMICS ISSN 1109-6535

Selective inhibition of CYP2C8 by fisetin and its methylated metabolite, geraldol, in human liver microsomes 성과년도 2018 성과 고유번호 JNL-2018-00110222665 학술지명 DRUG METABOLISM AND PHARMACOKINETICS ISSN 1347-4367

Terfenadone is a strong inhibitor of CYP2J2 present in the human liver and intestinal microsomes 성과년도 2018 성과 고유번호 JNL-2018-00110222637 학술지명 DRUG METABOLISM AND PHARMACOKINETICS ISSN 1347-4367

A Comprehensive In Vivo and In Vitro Assessment of the Drug Interaction Potential of Red Ginseng 성과년도 2018 성과 고유번호 JNL-2018-00110222642 학술지명 CLINICAL THERAPEUTICS ISSN 0149-2918

Metabolomic and lipidomic analysis of the effect of pioglitazone on hepatic steatosis in a rat model of obese Type 2 diabetes 성과년도 2018 성과 고유번호 JNL-2018-00110222643 학술지명 BRITISH JOURNAL OF PHARMACOLOGY ISSN 0007-1188

Testican-1, as a novel diagnosis of sepsis 성과년도 2018 성과 고유번호 JNL-2018-00110222656 학술지명 JOURNAL OF CELLULAR BIOCHEMISTRY ISSN 0730-2312

LRRK2 G2019S Induces Anxiety/Depression-like Behavior before the Onset of Motor Dysfunction with 5-HT1A Receptor Upregulation in Mice 성과년도 2018 성과 고유번호 JNL-2018-00110222632 학술지명 JOURNAL OF NEUROSCIENCE ISSN 0270-6474

Inhibitory Effect of Pelargonidin on Secretory Group IIA Phospholipase A2 성과년도 2018 성과 고유번호 JNL-2018-00110222660 학술지명 NATURAL PRODUCT COMMUNICATIONS ISSN 1934-578X

Renal protective effects of aspalathin and nothofagin from rooibos (Aspalathus linearis) in a mouse model of sepsis 성과년도 2018 성과 고유번호 JNL-2018-00110222662 학술지명 PHARMACOLOGICAL REPORTS ISSN 1734-1140

Phytosphingosine Increases Biosynthesis of Phytoceramide by Uniquely Stimulating the Expression of Dihydroceramide C4-desaturase (DES2) in Cultured Human Keratinocytes 성과년도 2018 성과 고유번호 JNL-2018-00110222644 학술지명 LIPIDS ISSN 0024-4201

Macrophagic Stabilin-1 Restored Disruption of Vascular Integrity Caused by Sepsis 성과년도 2018 성과 고유번호 JNL-2018-00110222661 학술지명 THROMBOSIS AND HAEMOSTASIS ISSN 0340-6245

Simultaneous Determination of Five Cytochrome P450 Probe Substrates and Their Metabolites and Organic Anion Transporting Polypeptide Probe Substrate in Human Plasma Using Liquid Chromatography-Tandem Mass Spectrometry 성과년도 2018 성과 고유번호 JNL-2018-00110222639 학술지명 PHARMACEUTICS ISSN 1999-4923

Terfenadone is a strong inhibitor of CYP2J2 present in the human liver and intestinal microsomes 성과년도 2018 성과 고유번호 JNL-2018-00110222637 학술지명 DRUG METABOLISM AND PHARMACOKINETICS ISSN 1347-4367

Exploring the Metabolism of Loxoprofen in Liver Microsomes: The Role of Cytochrome P450 and UDP-Glucuronosyltransferase in Its Biotransformation 성과년도 2018 성과 고유번호 JNL-2018-00110222674 학술지명 PHARMACEUTICS ISSN 1999-4923

Characterization of CYPs and UGTs Involved in Human Liver Microsomal Metabolism of Osthenol 성과년도 2018 성과 고유번호 JNL-2018-00110222676 학술지명 PHARMACEUTICS ISSN 1999-4923

Decursinol Angelate Inhibits LPS-Induced Macrophage Polarization through Modulation of the NF kappa B and MAPK Signaling Pathways 성과년도 2018 성과 고유번호 JNL-2018-00110222647 학술지명 MOLECULES ISSN 1420-3049

A Comprehensive In Vivo and In Vitro Assessment of the Drug Interaction Potential of Red Ginseng 성과년도 2018 성과 고유번호 JNL-2018-00110222642 학술지명 CLINICAL THERAPEUTICS ISSN 0149-2918

Metabolomic and lipidomic analysis of the effect of pioglitazone on hepatic steatosis in a rat model of obese Type 2 diabetes 성과년도 2018 성과 고유번호 JNL-2018-00110222643 학술지명 BRITISH JOURNAL OF PHARMACOLOGY ISSN 0007-1188

A Pharmacometabolomic Approach to Predict Response to Metformin in Early-Phase Type 2 Diabetes Mellitus Patients 성과년도 2018 성과 고유번호 JNL-2018-00110222638 학술지명 MOLECULES ISSN 1420-3049

The Ancient Phosphatidylinositol 3-Kinase Signaling System Is a Master Regulator of Energy and Carbon Metabolism in Algae 성과년도 2018 성과 고유번호 JNL-2018-00110222640 학술지명 PLANT PHYSIOLOGY ISSN 0032-0889

Palladium nanoparticle-decorated 2-D graphene oxide for effective photodynamic and photothermal therapy of prostate solid tumors 성과년도 2018 성과 고유번호 JNL-2018-00110222646 학술지명 COLLOIDS AND SURFACES B-BIOINTERFACES ISSN 0927-7765

Suppressive effects of zingerone on TGFBIp-mediated septic responses 성과년도 2018 성과 고유번호 JNL-2018-00110222655 학술지명 ARCHIVES OF PHARMACAL RESEARCH ISSN 0253-6269

Validation of a Multiresidue Analysis Method for 379 Pesticides in Human Serum Using Liquid Chromatography-Tandem Mass Spectrometry 성과년도 2018 성과 고유번호 JNL-2018-00110222635 학술지명 JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY ISSN 0021-8561

Quantitative Proteomic Analysis of Changes Related to Age and Calorie Restriction in Rat Liver Tissue 성과년도 2018 성과 고유번호 JNL-2018-00110222666 학술지명 PROTEOMICS ISSN 1615-9853

Cudratricusxanthone A attenuates sepsis-induced liver injury via SIRT1 signaling 성과년도 2018 성과 고유번호 JNL-2018-00110222659 학술지명 JOURNAL OF CELLULAR PHYSIOLOGY ISSN 0021-9541

Inhibitory Effects of Sulforaphane on Polyphosphate-mediated Septic Responses 성과년도 2018 성과 고유번호 JNL-2018-00110222648 학술지명 INTERNATIONAL JOURNAL OF PHARMACOLOGY ISSN 1811-7775

Non-targeted metabolomics-guided sildenafil metabolism study in human liver microsomes 성과년도 2018 성과 고유번호 JNL-2018-00110222663 학술지명 JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES ISSN 1570-0232

The inhibitory potential of Broussochalcone A for the human cytochrome P450 2J2 isoform and its anti-cancer effects via FOXO3 activation 성과년도 2018 성과 고유번호 JNL-2018-00110222633 학술지명 PHYTOMEDICINE ISSN 0944-7113

Selective inhibition of CYP2C8 by fisetin and its methylated metabolite, geraldol, in human liver microsomes 성과년도 2018 성과 고유번호 JNL-2018-00110222665 학술지명 DRUG METABOLISM AND PHARMACOKINETICS ISSN 1347-4367

Impaired permeability and antimicrobial barriers in type 2 diabetes skin are linked to increased serum levels of advanced glycation end-product 성과년도 2018 성과 고유번호 JNL-2018-00110222641 학술지명 EXPERIMENTAL DERMATOLOGY ISSN 0906-6705

Suppressive Effects of Zingerone on Polyphosphate-Mediated Vascular Inflammatory Responses 성과년도 2018 성과 고유번호 JNL-2018-00110222651 학술지명 INTERNATIONAL JOURNAL OF PHARMACOLOGY ISSN 1811-7775

Selective Inhibitory Effect of Osthenol on Human Cytochrome 2C8 성과년도 2018 성과 고유번호 JNL-2018-00110222669 학술지명 BULLETIN OF THE KOREAN CHEMICAL SOCIETY ISSN 0253-2964

Protective effects of zingerone on lipopolysaccharide-induced hepatic failure through the modulation of inflammatory pathways 성과년도 2018 성과 고유번호 JNL-2018-00110222653 학술지명 CHEMICO-BIOLOGICAL INTERACTIONS ISSN 0009-2797

Protective Effects of Pelargonidin on Lipopolysaccharide-induced Hepatic Failure 성과년도 2018 성과 고유번호 JNL-2018-00110222650 학술지명 NATURAL PRODUCT COMMUNICATIONS ISSN 1934-578X

Metabolic regulation of macrophages in tumor microenvironment 성과년도 2018 성과 고유번호 JNL-2018-00110222649 학술지명 CURRENT OPINION IN HEMATOLOGY ISSN 1065-6251

Inhibitory Effect of Sulforaphane on Secretory Group IIA Phospholipase A(2) 성과년도 2018 성과 고유번호 JNL-2018-00110222652 학술지명 INTERNATIONAL JOURNAL OF PHARMACOLOGY ISSN 1811-7775

Sulforaphane Suppresses Sepsis-Mediated Renal Functions in Cecal Ligation and Puncture Mouse Model 성과년도 2018 성과 고유번호 JNL-2018-00110222658 학술지명 NATURAL PRODUCT COMMUNICATIONS ISSN 1934-578X

Testican-1, as a novel diagnosis of sepsis 성과년도 2018 성과 고유번호 JNL-2018-00110222656 학술지명 JOURNAL OF CELLULAR BIOCHEMISTRY ISSN 0730-2312

Isolation, Synthesis, and Antisepsis Effects of a C-Methylcoumarinochromone Isolated from Abronia nano Cell Culture 성과년도 2018 성과 고유번호 JNL-2018-00110222657 학술지명 JOURNAL OF NATURAL PRODUCTS ISSN 0163-3864

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