국가 R&D 과제 조회
과제고유번호 1711065994 당해연도 연구기간 2018-03-01 ~ 2019-02-28
과제년도 2018 총 연구기간 2016-06-01 ~ 2019-02-28
주관부처명 과학기술정보통신부 연구기관명 성균관대학교(자연과학캠퍼스)
사업명 집단연구지원(R&D)
과제명 한글 레이트스테이지 약물 최적화 연구실
영문 Late-stage Drug Optimization Laboratory
연구개발단계 기초연구 지역 경기
6T분류 BT • 기초/기반기술 • 생명현상 및 기능연구
과학기술표준분류 의약품/의약품개발기술 / 의약품 합성/탐색

총 연구비
연도 정부 연구비(원) 민간 연구비(원) 사업예산
2018 500,000,000 0 500,000,000
관련 논문(31) 관련 특허(4) 관련 장비(0) 관련 보고서(0)

Novel therapeutic roles of MC-4 in combination with everolimus against advanced renal cell carcinoma by dual targeting of Akt/pyruvate kinase muscle isozyme M2 and mechanistic target of rapamycin comp...
성과년도
2018
성과 고유번호
JNL-2018-0019963974
학술지명
CANCER MEDICINE
ISSN
2045-7634
Synthesis of TMPA Derivatives through Sequential Ir(III)-Catalyzed C-H Alkylation and Their Antidiabetic Evaluation
성과년도
2018
성과 고유번호
JNL-2018-0019964196
학술지명
ACS OMEGA
ISSN
2470-1343
Reductive C2-Alkylation of Pyridine and Quinoline N-Oxides Using Wittig Reagents
성과년도
2018
성과 고유번호
JNL-2018-0019958820
학술지명
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
ISSN
1433-7851
Direct Synthesis of 2-Acyl Acridines Using Aldimines and Anthranils: Evaluation of Cytotoxicity and Anti-Inflammatory Activity
성과년도
2018
성과 고유번호
JNL-2018-0019959586
학술지명
ASIAN JOURNAL OF ORGANIC CHEMISTRY
ISSN
2193-5807
Synthesis of (2H)-Indazoles through Rh(III)-Catalyzed Annulation Reaction of Azobenzenes with Sulfoxonium Ylides
성과년도
2018
성과 고유번호
JNL-2018-0019958144
학술지명
JOURNAL OF ORGANIC CHEMISTRY
ISSN
0022-3263
Novel SIRT1 inhibitor 15-deoxy-Delta(12,14)-prostaglandin J(2) and its derivatives exhibit anticancer activity through apoptotic or autophagic cell death pathways in SKOV3 cells
성과년도
2018
성과 고유번호
JNL-2018-0019963748
학술지명
INTERNATIONAL JOURNAL OF ONCOLOGY
ISSN
1019-6439
Ru(II)-Catalyzed C-H Aminocarbonylation of N-(Hetero)aryl-7-azaindoles with Isocyanates
성과년도
2018
성과 고유번호
JNL-2018-0019958002
학술지명
JOURNAL OF ORGANIC CHEMISTRY
ISSN
0022-3263
Reactivity of Morita-Baylis-Hillman Adducts in C-H Functionalization of (Hetero)aryl Nitrones: Access to Bridged Cycles and Carbazoles
성과년도
2018
성과 고유번호
JNL-2018-0019959020
학술지명
ORGANIC LETTERS
ISSN
1523-7060
Dual Role of Anthranils as Amination and Transient Directing Group Sources: Synthesis of 2-Acyl Acridines
성과년도
2018
성과 고유번호
JNL-2018-0019958660
학술지명
ORGANIC LETTERS
ISSN
1523-7060
Site-selective C-H nitration of N-aryl-7-azaindoles under palladium(II) catalysis
성과년도
2018
성과 고유번호
JNL-2018-0019959800
학술지명
TETRAHEDRON LETTERS
ISSN
0040-4039
One-pot synthesis of 2-naphthols from nitrones and MBH adducts via decarboxylative N-O bond cleavage
성과년도
2018
성과 고유번호
JNL-2018-0019959802
학술지명
ORGANIC CHEMISTRY FRONTIERS
ISSN
2052-4129
Disparate Downstream Reactions Mediated by an lonically Controlled Supramolecular Tristate Switch
성과년도
2018
성과 고유번호
JNL-2018-0019958662
학술지명
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
ISSN
0002-7863
Afrocyclamin A, a triterpene saponin, induces apoptosis and autophagic cell death via the PI3K/Akt/mTOR pathway in human prostate cancer cells
성과년도
2018
성과 고유번호
JNL-2018-0019959762
학술지명
PHYTOMEDICINE
ISSN
0944-7113
A New Synthetic Histone Deacetylase Inhibitor, MHY2256, Induces Apoptosis and Autophagy Cell Death in Endometrial Cancer Cells via p53 Acetylation
성과년도
2018
성과 고유번호
JNL-2018-0019959756
학술지명
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
ISSN
1422-0067
Recent advances in N-heterocycles synthesis through catalytic C-H functionalization of azobenzenes
성과년도
2018
성과 고유번호
JNL-2018-0019959764
학술지명
TETRAHEDRON
ISSN
0040-4020
Synthesis of 2-Benzazepines from Benzylamines and MBH Adducts Under Rhodium(III) Catalysis via C(sp(2))-H Functionalization
성과년도
2018
성과 고유번호
JNL-2018-0019644959
학술지명
ACS CATALYSIS
ISSN
2155-5435
Novel SIRT1 inhibitor 15-deoxy-Delta(12,14)-prostaglandin J(2) and its derivatives exhibit anticancer activity through apoptotic or autophagic cell death pathways in SKOV3 cells
성과년도
2018
성과 고유번호
JNL-2018-0019963748
학술지명
INTERNATIONAL JOURNAL OF ONCOLOGY
ISSN
1019-6439
Recent advances in N-heterocycles synthesis through catalytic C-H functionalization of azobenzenes
성과년도
2018
성과 고유번호
JNL-2018-0019959764
학술지명
TETRAHEDRON
ISSN
0040-4020
One-pot synthesis of 2-naphthols from nitrones and MBH adducts via decarboxylative N-O bond cleavage
성과년도
2018
성과 고유번호
JNL-2018-0019959802
학술지명
ORGANIC CHEMISTRY FRONTIERS
ISSN
2052-4129
Site-selective C-H nitration of N-aryl-7-azaindoles under palladium(II) catalysis
성과년도
2018
성과 고유번호
JNL-2018-0019959800
학술지명
TETRAHEDRON LETTERS
ISSN
0040-4039
Reactivity of Morita-Baylis-Hillman Adducts in C-H Functionalization of (Hetero)aryl Nitrones: Access to Bridged Cycles and Carbazoles
성과년도
2018
성과 고유번호
JNL-2018-0019959020
학술지명
ORGANIC LETTERS
ISSN
1523-7060
Direct Synthesis of 2-Acyl Acridines Using Aldimines and Anthranils: Evaluation of Cytotoxicity and Anti-Inflammatory Activity
성과년도
2018
성과 고유번호
JNL-2018-0019959586
학술지명
ASIAN JOURNAL OF ORGANIC CHEMISTRY
ISSN
2193-5807
Reductive C2-Alkylation of Pyridine and Quinoline N-Oxides Using Wittig Reagents
성과년도
2018
성과 고유번호
JNL-2018-0019958820
학술지명
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
ISSN
1433-7851
Disparate Downstream Reactions Mediated by an lonically Controlled Supramolecular Tristate Switch
성과년도
2018
성과 고유번호
JNL-2018-0019958662
학술지명
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
ISSN
0002-7863
Dual Role of Anthranils as Amination and Transient Directing Group Sources: Synthesis of 2-Acyl Acridines
성과년도
2018
성과 고유번호
JNL-2018-0019958660
학술지명
ORGANIC LETTERS
ISSN
1523-7060
Synthesis of (2H)-Indazoles through Rh(III)-Catalyzed Annulation Reaction of Azobenzenes with Sulfoxonium Ylides
성과년도
2018
성과 고유번호
JNL-2018-0019958144
학술지명
JOURNAL OF ORGANIC CHEMISTRY
ISSN
0022-3263
A New Synthetic Histone Deacetylase Inhibitor, MHY2256, Induces Apoptosis and Autophagy Cell Death in Endometrial Cancer Cells via p53 Acetylation
성과년도
2018
성과 고유번호
JNL-2018-0019959756
학술지명
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
ISSN
1422-0067
Synthesis of TMPA Derivatives through Sequential Ir(III)-Catalyzed C-H Alkylation and Their Antidiabetic Evaluation
성과년도
2018
성과 고유번호
JNL-2018-0019964196
학술지명
ACS OMEGA
ISSN
2470-1343
Synthesis of 2-Benzazepines from Benzylamines and MBH Adducts Under Rhodium(III) Catalysis via C(sp(2))-H Functionalization
성과년도
2018
성과 고유번호
JNL-2018-0019644959
학술지명
ACS CATALYSIS
ISSN
2155-5435
Novel therapeutic roles of MC-4 in combination with everolimus against advanced renal cell carcinoma by dual targeting of Akt/pyruvate kinase muscle isozyme M2 and mechanistic target of rapamycin complex 1 pathways
성과년도
2018
성과 고유번호
JNL-2018-0019963974
학술지명
CANCER MEDICINE
ISSN
2045-7634
Afrocyclamin A, a triterpene saponin, induces apoptosis and autophagic cell death via the PI3K/Akt/mTOR pathway in human prostate cancer cells
성과년도
2018
성과 고유번호
JNL-2018-0019959762
학술지명
PHYTOMEDICINE
ISSN
0944-7113