출원등록명	2-(3-[2-(1-시클로헥센-1-일)에틸]-6,7-디메톡시-4-옥소-3,4-디히드로-2-퀴나졸리닐술파닐)-N-(4-에틸페닐)부탄아미드를 유효성분으로 포함하는 치매 치료 및 예방용 조성물
산업재산권 구분	특허	특허구분	출원
출원등록번호	10-2018-0116882	출원등록자	충북대학교 산학협력단
출원등록국가	대한민국	IPC 코드	A61K 31/517,A61P 25/28
성과년도	2018	NTIS 성과고유번호	PTR-2018-00210160606

종양 이환 네트워크 연구센터(Cancer Predisposing Network Research Center(cPRC)) 과제년도 2018 과제번호 1711065959 연구기관 충북대학교 연구기간 2018-03-01~2019-02-28

Identification of antioxidant constituents of the aerial part of Plantago asiatica using LC-MS/MS coupled DPPH assay 성과년도 2018 성과 고유번호 JNL-2018-00110107843 학술지명 PHYTOCHEMISTRY LETTERS ISSN 1874-3900

Metal-free approach for the L-proline mediated synthesis of nitrones from nitrosobenzene 성과년도 2018 성과 고유번호 JNL-2018-00110108327 학술지명 TETRAHEDRON ISSN 0040-4020

Transition-metal-free, atom-economical cascade synthesis of novel 2-sulfonated-benzo[f][1,7]naphthyridines and their cytotoxic activities 성과년도 2018 성과 고유번호 JNL-2018-00110107053 학술지명 TETRAHEDRON ISSN 0040-4020

CXCR3-deficient natural killer cells fail to migrate to B16F10 melanoma cells 성과년도 2018 성과 고유번호 JNL-2018-00110102805 학술지명 INTERNATIONAL IMMUNOPHARMACOLOGY ISSN 1567-5769

Phenolic amides from Tribulus terrestris and their inhibitory effects on nitric oxide production in RAW 264.7 cells 성과년도 2018 성과 고유번호 JNL-2018-00110101365 학술지명 ARCHIVES OF PHARMACAL RESEARCH ISSN 0253-6269

CXCR3-deficient mesenchymal stem cells fail to infiltrate into the nephritic kidney and do not ameliorate lupus symptoms in MRL.Fas(lpr) mice 성과년도 2018 성과 고유번호 JNL-2018-00110101367 학술지명 LUPUS ISSN 0961-2033

Lathyrane-Type Diterpenoids from the Seeds of Euphorbia lathyris L. with Inhibitory Effects on NO Production in RAW 264.7 Cells 성과년도 2018 성과 고유번호 JNL-2018-00110107111 학술지명 CHEMISTRY & BIODIVERSITY ISSN 1612-1872

Quinazoline-Based Hydroxamic Acids: Design, Synthesis, and Evaluation of Histone Deacetylase Inhibitory Effects and Cytotoxicity 성과년도 2018 성과 고유번호 JNL-2018-00110104265 학술지명 CHEMISTRY & BIODIVERSITY ISSN 1612-1872

Dimeric- and trimeric sesquiterpenes from the flower of Inula japonica 성과년도 2018 성과 고유번호 JNL-2018-00110104263 학술지명 PHYTOCHEMISTRY ISSN 0031-9422

Melanogenesis inhibitory pregnane glycosides from Cynanchum atratum 성과년도 2018 성과 고유번호 JNL-2018-00110102803 학술지명 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS ISSN 0960-894X

Effect of a Combination of Prednisone or Mycophenolate Mofetil and Mesenchymal Stem Cells on Lupus Symptoms in MRL.Fas(lPr) Mice 성과년도 2018 성과 고유번호 JNL-2018-00110101877 학술지명 STEM CELLS INTERNATIONAL ISSN 1687-966X

Novel Hydroxamic Acids Incorporating 1-((1H-1,2,3-Triazol-4-yl)methyl)-3-substituted-2-oxoindolines: Synthesis, Biological Evaluation and SAR Analysis 성과년도 2018 성과 고유번호 JNL-2018-00110101875 학술지명 MEDICINAL CHEMISTRY ISSN 1573-4064

Nitric oxide inhibitory constituents from Siegesbeckia pubescens 성과년도 2018 성과 고유번호 JNL-2018-00110101363 학술지명 BIOORGANIC CHEMISTRY ISSN 0045-2068

Novel hydroxamic acids incorporating 1-((1H-1,2,3-Triazol-4-yl)methyl)-3-hydroxyimino-indolin-2-ones: synthesis, biological evaluation, and SAR analysis 성과년도 2018 성과 고유번호 JNL-2018-00110101369 학술지명 JOURNAL OF CHEMICAL SCIENCES ISSN 0974-3626

Development of 13H-benzo[f]chromeno[4,3-b][1,7]naphthyridines and their salts as potent cytotoxic agents and topoisomerase I/II alpha inhibitors 성과년도 2018 성과 고유번호 JNL-2018-00110107859 학술지명 BIOORGANIC & MEDICINAL CHEMISTRY ISSN 0968-0896

Characterization of tyrosinase inhibitory constituents from the aerial parts of Humulus japonicus using LC-MS/MS coupled online assay 성과년도 2018 성과 고유번호 JNL-2018-00110106987 학술지명 BIOORGANIC & MEDICINAL CHEMISTRY ISSN 0968-0896

제2형 당뇨병성 말초신경병증을 치료하기 위한 항산화요법에 대한 고찰 성과년도 2018 성과 고유번호 JNL-2018-00110106967 학술지명 약 학 회 지 ISSN 0377-9556

alpha-Viniferin Improves Facial Hyperpigmentation via Accelerating Feedback Termination of cAMP/PKA-Signaled Phosphorylation Circuit in Facultative Melanogenesis 성과년도 2018 성과 고유번호 JNL-2018-00110107885 학술지명 THERANOSTICS ISSN 1838-7640

Organocatalytic and Regiodivergent Mannich Reaction of Ketones with Benzoxazinones 성과년도 2018 성과 고유번호 JNL-2018-00110108861 학술지명 ADVANCED SYNTHESIS & CATALYSIS ISSN 1615-4150

The role of lactose carrier on the powder behavior and aerodynamic performance of bosentan microparticles for dry powder inhalation 성과년도 2018 성과 고유번호 JNL-2018-00110107841 학술지명 EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES ISSN 0928-0987

Long-term Survival after Repeated Local Therapy and Salvage Chemotherapy for Recurrent Metastases from Gastric Cancer: a Case Report and Literature Review 성과년도 2018 성과 고유번호 JNL-2018-00110159072 학술지명 JOURNAL OF GASTRIC CANCER ISSN 2093-582x

Sleep-Aids Derived from Natural Products 성과년도 2018 성과 고유번호 JNL-2018-00110160252 학술지명 BIOMOLECULES & THERAPEUTICS ISSN 1976-9148

Feasibility and accessibility of electronic patient-reported outcome measures using a smartphone during routine chemotherapy: a pilot study 성과년도 2018 성과 고유번호 JNL-2018-00110155302 학술지명 SUPPORTIVE CARE IN CANCER ISSN 0941-4355

N-[(E)-Arylidene]-2-(2,3-dihydro-3-oxo-4H-1,4-benzoxazin-4-yl)-acetohydrazides: Synthesis and Evaluation of Caspase Activation Activity and Cytotoxicity 성과년도 2018 성과 고유번호 JNL-2018-00110104217 학술지명 CHEMISTRY & BIODIVERSITY ISSN 1612-1872

Rapid, Operationally Simple, and Metal-free NBS Mediated One-pot Synthesis of 1,2-Naphthoquinone from 2-Naphthol 성과년도 2018 성과 고유번호 JNL-2018-00110108113 학술지명 ADVANCED SYNTHESIS & CATALYSIS ISSN 1615-4150

Modulation of store-operated calcium entry and nascent adhesion by p21-activated kinase 1 성과년도 2018 성과 고유번호 JNL-2018-00110115543 학술지명 EXPERIMENTAL AND MOLECULAR MEDICINE ISSN 1226-3613

The contribution of toll-like receptor signaling to the development of liver fibrosis and cancer in hepatocyte-specific TAK1-deleted mice 성과년도 2018 성과 고유번호 JNL-2018-00110116685 학술지명 INTERNATIONAL JOURNAL OF CANCER ISSN 0020-7136

Dysregulation of 5-hydroxytryptamine 6 receptor accelerates maturation of bone-resorbing osteoclasts and induces bone loss 성과년도 2018 성과 고유번호 JNL-2018-00110116643 학술지명 THERANOSTICS ISSN 1838-7640

Toll-Like Receptor-7 Signaling Promotes Nonalcoholic Steatohepatitis by Inhibiting Regulatory T Cells in Mice 성과년도 2018 성과 고유번호 JNL-2018-00110115769 학술지명 AMERICAN JOURNAL OF PATHOLOGY ISSN 0002-9440

Astaxanthin alleviated ethanol-induced liver injury by inhibition of oxidative stress and inflammatory responses via blocking of STAT3 activity 성과년도 2018 성과 고유번호 JNL-2018-00110117437 학술지명 SCIENTIFIC REPORTS ISSN 2045-2322

Atherosclerosis is exacerbated by chitinase-3-like-1 in amyloid precursor protein transgenic mice 성과년도 2018 성과 고유번호 JNL-2018-00110116991 학술지명 THERANOSTICS ISSN 1838-7640

Estrogen deficiency exacerbates A beta-induced memory impairment through enhancement of neuroinflammation, amyloidogenesis and NF-kappa B activation in ovariectomized mice 성과년도 2018 성과 고유번호 JNL-2018-00110116573 학술지명 BRAIN BEHAVIOR AND IMMUNITY ISSN 0889-1591

Peptide nucleic acid (PNA) probe-based analysis to detect filaggrin mutations in atopic dermatitis patients 성과년도 2018 성과 고유번호 JNL-2018-00110117359 학술지명 EXPERIMENTAL DERMATOLOGY ISSN 0906-6705

Suppression of metastasis through inhibition of chitinase 3-like 1 expression by miR-125a-3p-mediated up-regulation of USF1 성과년도 2018 성과 고유번호 JNL-2018-00110117419 학술지명 THERANOSTICS ISSN 1838-7640

Anti-inflammatory effect of Centella asiatica phytosome in a mouse model of phthalic anhydride-induced atopic dermatitis 성과년도 2018 성과 고유번호 JNL-2018-00110115645 학술지명 PHYTOMEDICINE ISSN 0944-7113

Inhibition of skin carcinogenesis by suppression of NF-kappa B dependent ITGAV and TIMP-1 expression in IL-32 gamma overexpressed condition 성과년도 2018 성과 고유번호 JNL-2018-00110116707 학술지명 JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH ISSN 1756-9966

IL-32 gamma reduces lung tumor development through upregulation of TIMP-3 overexpression and hypomethylation 성과년도 2018 성과 고유번호 JNL-2018-00110115765 학술지명 CELL DEATH & DISEASE ISSN 2041-4889

K284-6111 prevents the amyloid beta-induced neuroinflammation and impairment of recognition memory through inhibition of NF-kappa B-mediated CHI3L1 expression 성과년도 2018 성과 고유번호 JNL-2018-00110117439 학술지명 JOURNAL OF NEUROINFLAMMATION ISSN 1742-2094

Deficiency of parkin suppresses melanoma tumor development and metastasis through inhibition of MFN2 ubiquitination 성과년도 2018 성과 고유번호 JNL-2018-00110116973 학술지명 CANCER LETTERS ISSN 0304-3835

Thapsigargin Increases IL-2 Production in T Cells at Nanomolar Concentrations 성과년도 2018 성과 고유번호 JNL-2018-00110116993 학술지명 IMMUNE NETWORK ISSN 1598-2629

Piperlongumine Improves Lipopolysaccharide-Induced Amyloidogenesis by Suppressing NF-KappaB Pathway 성과년도 2018 성과 고유번호 JNL-2018-00110116145 학술지명 NEUROMOLECULAR MEDICINE ISSN 1535-1084

A novel tubulin inhibitor STK899704 induces tumor regression in DMBA/TPA-induced skin carcinogenesis model 성과년도 2018 성과 고유번호 JNL-2018-00110117237 학술지명 EXPERIMENTAL DERMATOLOGY ISSN 0906-6705

Design, synthesis and evaluation of novel N-hydroxybenzamides/N-hydroxypropenamides incorporating quinazolin-4(3H)-ones as histone deacetylase inhibitors and antitumor agents 성과년도 2018 성과 고유번호 JNL-2018-0019685471 학술지명 BIOORGANIC CHEMISTRY ISSN 0045-2068

Feasibility and accessibility of electronic patient-reported outcome measures using a smartphone during routine chemotherapy: a pilot study 성과년도 2018 성과 고유번호 JNL-2018-00110155302 학술지명 SUPPORTIVE CARE IN CANCER ISSN 0941-4355

Design, synthesis and evaluation of novel N-hydroxybenzamides/N-hydroxypropenamides incorporating quinazolin-4(3H)-ones as histone deacetylase inhibitors and antitumor agents 성과년도 2018 성과 고유번호 JNL-2018-0019685471 학술지명 BIOORGANIC CHEMISTRY ISSN 0045-2068

Novel Hydroxamic Acids Incorporating 1-((1H-1,2,3-Triazol-4-yl)methyl)-3-substituted-2-oxoindolines: Synthesis, Biological Evaluation and SAR Analysis 성과년도 2018 성과 고유번호 JNL-2018-00110101875 학술지명 MEDICINAL CHEMISTRY ISSN 1573-4064

Dysregulation of 5-hydroxytryptamine 6 receptor accelerates maturation of bone-resorbing osteoclasts and induces bone loss 성과년도 2018 성과 고유번호 JNL-2018-00110116643 학술지명 THERANOSTICS ISSN 1838-7640

Organocatalytic and Regiodivergent Mannich Reaction of Ketones with Benzoxazinones 성과년도 2018 성과 고유번호 JNL-2018-00110108861 학술지명 ADVANCED SYNTHESIS & CATALYSIS ISSN 1615-4150

CXCR3-deficient mesenchymal stem cells fail to infiltrate into the nephritic kidney and do not ameliorate lupus symptoms in MRL.Fas(lpr) mice 성과년도 2018 성과 고유번호 JNL-2018-00110101367 학술지명 LUPUS ISSN 0961-2033

Development of 13H-benzo[f]chromeno[4,3-b][1,7]naphthyridines and their salts as potent cytotoxic agents and topoisomerase I/II alpha inhibitors 성과년도 2018 성과 고유번호 JNL-2018-00110107859 학술지명 BIOORGANIC & MEDICINAL CHEMISTRY ISSN 0968-0896

Toll-Like Receptor-7 Signaling Promotes Nonalcoholic Steatohepatitis by Inhibiting Regulatory T Cells in Mice 성과년도 2018 성과 고유번호 JNL-2018-00110115769 학술지명 AMERICAN JOURNAL OF PATHOLOGY ISSN 0002-9440

Dimeric- and trimeric sesquiterpenes from the flower of Inula japonica 성과년도 2018 성과 고유번호 JNL-2018-00110104263 학술지명 PHYTOCHEMISTRY ISSN 0031-9422

Suppression of metastasis through inhibition of chitinase 3-like 1 expression by miR-125a-3p-mediated up-regulation of USF1 성과년도 2018 성과 고유번호 JNL-2018-00110117419 학술지명 THERANOSTICS ISSN 1838-7640

Estrogen deficiency exacerbates A beta-induced memory impairment through enhancement of neuroinflammation, amyloidogenesis and NF-kappa B activation in ovariectomized mice 성과년도 2018 성과 고유번호 JNL-2018-00110116573 학술지명 BRAIN BEHAVIOR AND IMMUNITY ISSN 0889-1591

CXCR3-deficient natural killer cells fail to migrate to B16F10 melanoma cells 성과년도 2018 성과 고유번호 JNL-2018-00110102805 학술지명 INTERNATIONAL IMMUNOPHARMACOLOGY ISSN 1567-5769

Lathyrane-Type Diterpenoids from the Seeds of Euphorbia lathyris L. with Inhibitory Effects on NO Production in RAW 264.7 Cells 성과년도 2018 성과 고유번호 JNL-2018-00110107111 학술지명 CHEMISTRY & BIODIVERSITY ISSN 1612-1872

Thapsigargin Increases IL-2 Production in T Cells at Nanomolar Concentrations 성과년도 2018 성과 고유번호 JNL-2018-00110116993 학술지명 IMMUNE NETWORK ISSN 1598-2629

Astaxanthin alleviated ethanol-induced liver injury by inhibition of oxidative stress and inflammatory responses via blocking of STAT3 activity 성과년도 2018 성과 고유번호 JNL-2018-00110117437 학술지명 SCIENTIFIC REPORTS ISSN 2045-2322

Metal-free approach for the L-proline mediated synthesis of nitrones from nitrosobenzene 성과년도 2018 성과 고유번호 JNL-2018-00110108327 학술지명 TETRAHEDRON ISSN 0040-4020

Piperlongumine Improves Lipopolysaccharide-Induced Amyloidogenesis by Suppressing NF-KappaB Pathway 성과년도 2018 성과 고유번호 JNL-2018-00110116145 학술지명 NEUROMOLECULAR MEDICINE ISSN 1535-1084

Deficiency of parkin suppresses melanoma tumor development and metastasis through inhibition of MFN2 ubiquitination 성과년도 2018 성과 고유번호 JNL-2018-00110116973 학술지명 CANCER LETTERS ISSN 0304-3835

Identification of antioxidant constituents of the aerial part of Plantago asiatica using LC-MS/MS coupled DPPH assay 성과년도 2018 성과 고유번호 JNL-2018-00110107843 학술지명 PHYTOCHEMISTRY LETTERS ISSN 1874-3900

Effect of a Combination of Prednisone or Mycophenolate Mofetil and Mesenchymal Stem Cells on Lupus Symptoms in MRL.Fas(lPr) Mice 성과년도 2018 성과 고유번호 JNL-2018-00110101877 학술지명 STEM CELLS INTERNATIONAL ISSN 1687-966X

Long-term Survival after Repeated Local Therapy and Salvage Chemotherapy for Recurrent Metastases from Gastric Cancer: a Case Report and Literature Review 성과년도 2018 성과 고유번호 JNL-2018-00110159072 학술지명 JOURNAL OF GASTRIC CANCER ISSN 2093-582x

Transition-metal-free, atom-economical cascade synthesis of novel 2-sulfonated-benzo[f][1,7]naphthyridines and their cytotoxic activities 성과년도 2018 성과 고유번호 JNL-2018-00110107053 학술지명 TETRAHEDRON ISSN 0040-4020

Nitric oxide inhibitory constituents from Siegesbeckia pubescens 성과년도 2018 성과 고유번호 JNL-2018-00110101363 학술지명 BIOORGANIC CHEMISTRY ISSN 0045-2068

Peptide nucleic acid (PNA) probe-based analysis to detect filaggrin mutations in atopic dermatitis patients 성과년도 2018 성과 고유번호 JNL-2018-00110117359 학술지명 EXPERIMENTAL DERMATOLOGY ISSN 0906-6705

N-[(E)-Arylidene]-2-(2,3-dihydro-3-oxo-4H-1,4-benzoxazin-4-yl)-acetohydrazides: Synthesis and Evaluation of Caspase Activation Activity and Cytotoxicity 성과년도 2018 성과 고유번호 JNL-2018-00110104217 학술지명 CHEMISTRY & BIODIVERSITY ISSN 1612-1872

K284-6111 prevents the amyloid beta-induced neuroinflammation and impairment of recognition memory through inhibition of NF-kappa B-mediated CHI3L1 expression 성과년도 2018 성과 고유번호 JNL-2018-00110117439 학술지명 JOURNAL OF NEUROINFLAMMATION ISSN 1742-2094

Phenolic amides from Tribulus terrestris and their inhibitory effects on nitric oxide production in RAW 264.7 cells 성과년도 2018 성과 고유번호 JNL-2018-00110101365 학술지명 ARCHIVES OF PHARMACAL RESEARCH ISSN 0253-6269

A novel tubulin inhibitor STK899704 induces tumor regression in DMBA/TPA-induced skin carcinogenesis model 성과년도 2018 성과 고유번호 JNL-2018-00110117237 학술지명 EXPERIMENTAL DERMATOLOGY ISSN 0906-6705

IL-32 gamma reduces lung tumor development through upregulation of TIMP-3 overexpression and hypomethylation 성과년도 2018 성과 고유번호 JNL-2018-00110115765 학술지명 CELL DEATH & DISEASE ISSN 2041-4889

Inhibition of skin carcinogenesis by suppression of NF-kappa B dependent ITGAV and TIMP-1 expression in IL-32 gamma overexpressed condition 성과년도 2018 성과 고유번호 JNL-2018-00110116707 학술지명 JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH ISSN 1756-9966

Atherosclerosis is exacerbated by chitinase-3-like-1 in amyloid precursor protein transgenic mice 성과년도 2018 성과 고유번호 JNL-2018-00110116991 학술지명 THERANOSTICS ISSN 1838-7640

Quinazoline-Based Hydroxamic Acids: Design, Synthesis, and Evaluation of Histone Deacetylase Inhibitory Effects and Cytotoxicity 성과년도 2018 성과 고유번호 JNL-2018-00110104265 학술지명 CHEMISTRY & BIODIVERSITY ISSN 1612-1872

Sleep-Aids Derived from Natural Products 성과년도 2018 성과 고유번호 JNL-2018-00110160252 학술지명 BIOMOLECULES & THERAPEUTICS ISSN 1976-9148

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