출원등록명	β-아포피크로포도필린을 유효 성분으로 포함하는 항암제 및 방사선 치료 증진제
산업재산권 구분	특허	특허구분	출원
출원등록번호	10-2018-0043274	출원등록자	한국원자력의학원
출원등록국가	대한민국	IPC 코드	A61K 31/36,A61K 9/00,A61P 35/00
성과년도	2018	NTIS 성과고유번호	PTO-2018-00210241395

방사선반응제어 실용화기술개발 과제년도 2018 과제번호 1711072864 연구기관 한국원자력의학원 연구기간 2018-01-01~2018-12-31

Transcriptional Repression of High-Mobility Group Box 2 by p21 in Radiation-Induced Senescence 성과년도 2018 성과 고유번호 JNL-2018-00110241394 학술지명 MOLECULES AND CELLS ISSN 1016-8478

Anticancer and radiosensitizing effects of the cyclin-dependent kinase inhibitors, AT7519 and SNS-032, on cervical cancer 성과년도 2018 성과 고유번호 JNL-2018-00110241393 학술지명 INTERNATIONAL JOURNAL OF ONCOLOGY ISSN 1019-6439

TMEM165, a Golgi transmembrane protein, is a novel marker for hepatocellular carcinoma and its depletion impairs invasion activity 성과년도 2018 성과 고유번호 JNL-2018-00110241388 학술지명 ONCOLOGY REPORTS ISSN 1021-335X

Pro-apoptotic Bax promotes mesenchymal-epithelial transition by binding to respiratory complex-I and antagonizing the malignant actions of pro-survival Bcl-2 proteins 성과년도 2018 성과 고유번호 JNL-2018-00110241391 학술지명 Cancer Letters ISSN 0304-3835

miR-93-5p suppresses cellular senescence by directly targeting Bcl-w and p21 성과년도 2018 성과 고유번호 JNL-2018-00110241378 학술지명 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS ISSN 0006-291X

Bcl-2 Protein Targeting by the p53/p21 Complex-Response 성과년도 2018 성과 고유번호 JNL-2018-00110241392 학술지명 CANCER RESEARCH ISSN 0008-5472

MASTL inhibition promotes mitotic catastrophe through PP2A activation to inhibit cancer growth and radioresistance in breast cancer cells 성과년도 2018 성과 고유번호 JNL-2018-00110241389 학술지명 BMC CANCER ISSN 1471-2407

Imatinib mesylate elicits extracellular signal-related kinase (ERK) activation and enhances the survival of gamma-irradiated epithelial cells 성과년도 2018 성과 고유번호 JNL-2018-00110241379 학술지명 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS ISSN 0006-291X

3D Bioprinting Technologies for Tissue Engineering Applications 성과년도 2018 성과 고유번호 JNL-2018-00110241386 학술지명 Advances in Experimental Medicine and Biology ISSN 0065-2598

Effect of the pore size in a 3D bioprinted gelatin scaffold on fibroblast proliferation 성과년도 2018 성과 고유번호 JNL-2018-00110241383 학술지명 JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY ISSN 1226-086X

Tumour-vasculature development via endothelial-to-mesenchymal transition after radiotherapy controls CD44v6(+) cancer cell and macrophage polarization 성과년도 2018 성과 고유번호 JNL-2018-00110241377 학술지명 NATURE COMMUNICATIONS ISSN 2041-1723

A novel anti-cancer role of beta-apopicropodophyllin against non-small cell lung cancer cells 성과년도 2018 성과 고유번호 JNL-2018-00110241387 학술지명 TOXICOLOGY AND APPLIED PHARMACOLOGY ISSN 0041-008X

PLOD3 promotes lung metastasis via regulation of STAT3 성과년도 2018 성과 고유번호 JNL-2018-00110241381 학술지명 CELL DEATH & DISEASE ISSN 2041-4889

Functional Biological Activity of Sorafenib as a Tumor-Treating Field Sensitizer for Glioblastoma Therapy 성과년도 2018 성과 고유번호 JNL-2018-00110241376 학술지명 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES ISSN 1422-0067

생체 전기물성 기반 암 진단 및 치료효과 모니터링 연구 성과년도 2018 성과 고유번호 JNL-2018-00110241384 학술지명 전자공학회지 ISSN 1016-9288

Selective toxicity of tumor treating fields to melanoma: an in vitro and in vivo study 성과년도 2018 성과 고유번호 JNL-2018-00110241375 학술지명 CELL DEATH DISCOVERY ISSN 2058-7716

MicroRNA miR-4779 suppresses tumor growth by inducing apoptosis and cell cycle arrest through direct targeting of PAK2 and CCND3 성과년도 2018 성과 고유번호 JNL-2018-00110241390 학술지명 CELL DEATH & DISEASE ISSN 2041-4889

Centrosome Clustering Is a Tumor-selective Target for the Improvement of Radiotherapy in Breast Cancer Cells 성과년도 2018 성과 고유번호 JNL-2018-00110241385 학술지명 ANTICANCER RESEARCH ISSN 0250-7005

Oridonin Enhances Radiation-Induced Cell Death by Promoting DNA Damage in Non-Small Cell Lung Cancer Cells 성과년도 2018 성과 고유번호 JNL-2018-00110241380 학술지명 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES ISSN 1422-0067

Decreased Hepatic Lactotransferrin Induces Hepatic Steatosis in Chronic Non-Alcoholic Fatty Liver Disease Model 성과년도 2018 성과 고유번호 JNL-2018-00110241382 학술지명 CELLULAR PHYSIOLOGY AND BIOCHEMISTRY ISSN 1015-8987

Kinesin light chain-4 depletion induces apoptosis of radioresistant cancer cells by mitochondrial dysfunction via calcium ion influx 성과년도 2018 성과 고유번호 JNL-2018-0019684952 학술지명 CELL DEATH & DISEASE ISSN 2041-4889

The small molecule AU14022 promotes colorectal cancer cell death via p53-mediated G2/M-phase arrest and mitochondria-mediated apoptosis 성과년도 2018 성과 고유번호 JNL-2018-0019684949 학술지명 JOURNAL OF CELLULAR PHYSIOLOGY ISSN 0021-9541

3D Bioprinting Technologies for Tissue Engineering Applications 성과년도 2018 성과 고유번호 JNL-2018-00110241386 학술지명 Advances in Experimental Medicine and Biology ISSN 0065-2598

PLOD3 promotes lung metastasis via regulation of STAT3 성과년도 2018 성과 고유번호 JNL-2018-00110241381 학술지명 CELL DEATH & DISEASE ISSN 2041-4889

Imatinib mesylate elicits extracellular signal-related kinase (ERK) activation and enhances the survival of gamma-irradiated epithelial cells 성과년도 2018 성과 고유번호 JNL-2018-00110241379 학술지명 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS ISSN 0006-291X

Centrosome Clustering Is a Tumor-selective Target for the Improvement of Radiotherapy in Breast Cancer Cells 성과년도 2018 성과 고유번호 JNL-2018-00110241385 학술지명 ANTICANCER RESEARCH ISSN 0250-7005

miR-93-5p suppresses cellular senescence by directly targeting Bcl-w and p21 성과년도 2018 성과 고유번호 JNL-2018-00110241378 학술지명 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS ISSN 0006-291X

Effect of the pore size in a 3D bioprinted gelatin scaffold on fibroblast proliferation 성과년도 2018 성과 고유번호 JNL-2018-00110241383 학술지명 JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY ISSN 1226-086X

Tumour-vasculature development via endothelial-to-mesenchymal transition after radiotherapy controls CD44v6(+) cancer cell and macrophage polarization 성과년도 2018 성과 고유번호 JNL-2018-00110241377 학술지명 NATURE COMMUNICATIONS ISSN 2041-1723

Oridonin Enhances Radiation-Induced Cell Death by Promoting DNA Damage in Non-Small Cell Lung Cancer Cells 성과년도 2018 성과 고유번호 JNL-2018-00110241380 학술지명 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES ISSN 1422-0067

A novel anti-cancer role of beta-apopicropodophyllin against non-small cell lung cancer cells 성과년도 2018 성과 고유번호 JNL-2018-00110241387 학술지명 TOXICOLOGY AND APPLIED PHARMACOLOGY ISSN 0041-008X

Decreased Hepatic Lactotransferrin Induces Hepatic Steatosis in Chronic Non-Alcoholic Fatty Liver Disease Model 성과년도 2018 성과 고유번호 JNL-2018-00110241382 학술지명 CELLULAR PHYSIOLOGY AND BIOCHEMISTRY ISSN 1015-8987

TMEM165, a Golgi transmembrane protein, is a novel marker for hepatocellular carcinoma and its depletion impairs invasion activity 성과년도 2018 성과 고유번호 JNL-2018-00110241388 학술지명 ONCOLOGY REPORTS ISSN 1021-335X

MASTL inhibition promotes mitotic catastrophe through PP2A activation to inhibit cancer growth and radioresistance in breast cancer cells 성과년도 2018 성과 고유번호 JNL-2018-00110241389 학술지명 BMC CANCER ISSN 1471-2407

The small molecule AU14022 promotes colorectal cancer cell death via p53-mediated G2/M-phase arrest and mitochondria-mediated apoptosis 성과년도 2018 성과 고유번호 JNL-2018-0019684949 학술지명 JOURNAL OF CELLULAR PHYSIOLOGY ISSN 0021-9541

Selective toxicity of tumor treating fields to melanoma: an in vitro and in vivo study 성과년도 2018 성과 고유번호 JNL-2018-00110241375 학술지명 CELL DEATH DISCOVERY ISSN 2058-7716

Anticancer and radiosensitizing effects of the cyclin-dependent kinase inhibitors, AT7519 and SNS-032, on cervical cancer 성과년도 2018 성과 고유번호 JNL-2018-00110241393 학술지명 INTERNATIONAL JOURNAL OF ONCOLOGY ISSN 1019-6439

Functional Biological Activity of Sorafenib as a Tumor-Treating Field Sensitizer for Glioblastoma Therapy 성과년도 2018 성과 고유번호 JNL-2018-00110241376 학술지명 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES ISSN 1422-0067

MicroRNA miR-4779 suppresses tumor growth by inducing apoptosis and cell cycle arrest through direct targeting of PAK2 and CCND3 성과년도 2018 성과 고유번호 JNL-2018-00110241390 학술지명 CELL DEATH & DISEASE ISSN 2041-4889

Transcriptional Repression of High-Mobility Group Box 2 by p21 in Radiation-Induced Senescence 성과년도 2018 성과 고유번호 JNL-2018-00110241394 학술지명 MOLECULES AND CELLS ISSN 1016-8478

Kinesin light chain-4 depletion induces apoptosis of radioresistant cancer cells by mitochondrial dysfunction via calcium ion influx 성과년도 2018 성과 고유번호 JNL-2018-0019684952 학술지명 CELL DEATH & DISEASE ISSN 2041-4889

Pro-apoptotic Bax promotes mesenchymal-epithelial transition by binding to respiratory complex-I and antagonizing the malignant actions of pro-survival Bcl-2 proteins 성과년도 2018 성과 고유번호 JNL-2018-00110241391 학술지명 Cancer Letters ISSN 0304-3835

Bcl-2 Protein Targeting by the p53/p21 Complex-Response 성과년도 2018 성과 고유번호 JNL-2018-00110241392 학술지명 CANCER RESEARCH ISSN 0008-5472

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