Organic Reactions & Processes - Innovation in Synthetic Organic Methods and Strategies: Enabling the Processes of Tomorrow
원문 링크주관기관
Gordon Research Conference
행사장소
Bates College Lewiston, ME
행사기간
2015-07-19 ~ 2015-07-24
Application Deadline
This meeting is currently oversubscribed (full). You may still an application. However, it will only be considered by the Conference Chair if more seats become available due to cancellations.
Meeting Deion
The 2015 Gordon Research Conference (GRC) on Organic Reactions and Processes marks its 62nd anniversary, and will highlight outstanding contributions to synthetic organic chemistry. This year’s conference, co-chaired by Jade Nelson (Pfizer) and Jared Piper (Eli Lilly & Company), will be held at Bates College in Lewiston, Maine from July 19-24th, 2015. This location represents a in venue for the OR&P GRC, which has been held at Bryant University in Rhode Island for several years. Bates College offers comfortable accommodations, an excellent dining service, a broad range of leisure activities, and a superb New England location within easy access from Portland, ME or Boston, MA.
Consistent with the rich history of the Organic Reactions and Processes GRC, the 2015 program is comprised of a unique blend of industrial and academic participants, and includes both established and emerging young investigators from around the world. Our GRC offers the podium to dynamic, world recognized lecturers, and we continue to evolve and stay current in the central science that is chemistry. Diverse topics ranging from total synthesis, organocatalysis and non-precious metal catalysis, to the development of commercial manufacturing processes for active pharmaceutical ingredients will be presented. A session dedicated to emerging topics and novel therapies, such as antibody drug-conjugate development, computational methods, and continuous processing will be included.
In addition to the oral lecture program, a series of energizing poster sessions highlighting unpublished work from the laboratories of a large percentage of conference attendees will be featured. A subset of posters from these sessions will be ed to present short oral talks on Thursday morning.
Meeting Program
| Sunday | |
| 2:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
| 7:40 pm - 9:30 pm | New Synthetic Methods |
| Discussion Leader: Kevin Brown (Indiana University, USA) | |
| 7:40 pm - 8:25 pm | Paul Knochel (Ludwig-Maximilians University, Germany) "Polyfunctional Organometallics in Organic Synthesis" |
| 8:25 pm - 8:35 pm | Discussion |
| 8:35 pm - 9:20 pm | Scott Denmark (University of Illinois, USA) "Recent Advances in Preparative and Mechanistic Aspects of New Synthetic Methods" |
| 9:20 pm - 9:30 pm | Discussion |
| Monday | |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am | Group Photo |
| 9:00 am - 12:30 pm | Advances in Catalysis |
| Discussion Leaders: Mark Biscoe (The City College of New York, USA) and Amelie Dion (Pfizer, USA) | |
| 9:00 am - 9:35 am | Michael Willis (University of Oxford, United Kingdom) "Taming Sulfur Dioxide for Synthesis and Catalysis" |
| 9:35 am - 9:45 am | Discussion |
| 9:45 am - 10:20 am | Cathleen Crudden (Queen's University, Canada) "Chiral Organo Boranes: Substrates and Catalysts in Organic Transformations" |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am - 11:00 am | Coffee Break |
| 11:00 am - 11:35 am | Guangbin Dong (University of Texas at Austin, USA) "C-H Functionalization Based on Common Functional Groups" |
| 11:35 am - 11:45 am | Discussion |
| 11:45 am - 12:20 pm | Neil Garg (University of California, Los Angeles, USA) "Recent Advances in Non-Precious Metal Catalysis" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Process Development and Structure, Function and Mechanism |
| Discussion Leader: Kami Hull (University of Illinois, Urbana-Champaign, USA) | |
| 7:30 pm - 8:00 pm | Nathan Ide (Pfizer, Inc., USA) "Development of a Commercial Manufacturing Process for Ibrance® (palbociclib)" |
| 8:00 pm - 8:05 pm | Discussion |
| 8:05 pm - 8:35 pm | Kevin Cole (Eli Lilly and Company, USA) "A Case Study in Continuous Processing Under cGMP" |
| 8:35 pm - 8:40 pm | Discussion |
| 8:40 pm - 9:20 pm | Kendall Houk (University of California, Los Angeles, USA) "Elucidation of Mechanisms and Selectivities of Catalytic Reactions Through Computations" |
| 9:20 pm - 9:30 pm | Discussion |
| Tuesday | |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | New Chemical Technologies |
| Discussion Leaders: Jennifer Koviach-Cote (Bates College, USA) and Michael Zacuto (Celgene, USA) | |
| 9:00 am - 9:35 am | Emily Balskus (Harvard University, USA) "Biocompatible Chemistry" |
| 9:35 am - 9:45 am | Discussion |
| 9:45 am - 10:20 am | Al Garofalo (Catalent Biologics, USA) "Site-Specific ADCs; Linker Composition, Tag Placement, and Bioorthogonal Ligation Strategies" |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am - 11:00 am | Coffee Break |
| 11:00 am - 11:35 am | Suzanne Blum (University of California, Irvine, USA) "Oxyboration: Addition of the B-O Sigma Bond to Carbon-Carbon Pi Bonds" |
| 11:35 am - 11:45 am | Discussion |
| 11:45 am - 12:20 pm | Shannon Stahl (University of Wisconsin-Madison, USA) "Aerobic Oxidation Reactions for Pharmaceutical (Including Process Scale) Synthesis" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Process Development and Catalytic Methods |
| Discussion Leader: Jacqueline Milne (Amgen, USA) | |
| 7:30 pm - 8:00 pm | Jonathan Reeves (Boehringer Ingelheim Pharmaceuticals, USA) "Development of Safe and Scalable Processes for API Synthesis" |
| 8:00 pm - 8:05 pm | Discussion |
| 8:05 pm - 8:35 pm | Richard Fox (Bristol-Myers Squibb, USA) "Highlights in the Development of a Commercial Synthesis for a Late-Stage Active Pharmaceutical Ingredient" |
| 8:35 pm - 8:40 pm | Discussion |
| 8:40 pm - 9:20 pm | Karl Scheidt (Northwestern University, USA) "Cooperative Catalysis Strategies for Synthesis" |
| 9:20 pm - 9:30 pm | Discussion |
| Wednesday | |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Synthetic Methods and Strategies |
| Discussion Leaders: Silvia Diez-Gonzalez (Imperial College London, United Kingdom) and Amy DeBaillie (Eli Lilly & Company, USA) | |
| 9:00 am - 9:35 am | Kenichiro Itami (Nagoya University, Japan) "Materials- and Biology-Oriented C-H Activation" |
| 9:35 am - 9:45 am | Discussion |
| 9:45 am - 10:20 am | Cristina Nevado (University of Zurich, Switzerland) "If Metals Could Talk..." |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am - 11:00 am | Coffee Break |
| 11:00 am - 11:35 am | Daniel Weix (University of Rochester, USA) "Cross-Electrophile Coupling via Synergistic Catalysis" |
| 11:35 am - 11:45 am | Discussion |
| 11:45 am - 12:20 pm | Corey Stephenson (University of Michigan, USA) "Visible Light Mediated Free Radical Chemistry" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair | |
| 7:30 pm - 9:30 pm | Process Development and Non-Precious Metal Catalysis |
| Discussion Leader: Shashank Shekhar (Abbvie, USA) | |
| 7:30 pm - 8:00 pm | Kevin Campos (Merck & Co., Inc., USA) "Application of Novel Catalytic Asymmetric Reactions to the Manufacture of Merck Products" |
| 8:00 pm - 8:05 pm | Discussion |
| 8:05 pm - 8:35 pm | Chong Han (Genentech, Inc., USA) "Harnessing the Reactivity of 7-Azaindole for the Manufacturing Process of a Small Molecule Kinase Inhibitor" |
| 8:35 pm - 8:40 pm | Discussion |
| 8:40 pm - 9:20 pm | Paul Chirik (Princeton University, USA) "Base Metal Catalysis for Organic Synthesis" |
| 9:20 pm - 9:30 pm | Discussion |
| Thursday | |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Complex Molecular Synthesis / Selected Poster Presentations |
| Discussion Leaders: Kenneth Fraunhoffer (Bristol-Myers Squibb, USA) and Neal Anderson (Anderson's Process Solutions LLC, USA) | |
| 9:00 am - 9:35 am | Jeremy Wulff (University of Victoria, Canada) "Total Synthesis and Biological Exploitation of Complex Unnatural Products" |
| 9:35 am - 9:45 am | Discussion |
| 9:45 am - 10:20 am | Christopher Vanderwal (University of California, USA) "Analogue-Oriented Synthesis of Complex, Bioactive Natural Products" |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am - 10:45 am | Coffee Break |
| 10:45 am - 11:20 am | Timothy Jamison (Massachusetts Institute of Technology, USA) "Continuous Flow Multistep Synthesis" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 12:30 pm | Short Talks Selected from Poster Abstracts |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Keynote Session: Chemistry: The Central Science |
| Discussion Leader: Vy Dong (University of California - Irvine, USA) | |
| 7:30 pm - 8:00 pm | Eric Fang (Amgen, USA) "Development of a Robust Process for a C-Met Inhibitor" |
| 8:00 pm - 8:05 pm | Discussion |
| 8:05 pm - 8:35 pm | Pascal Dube (Nalas Engineering, USA) "Development of Safe and Practical Oxidation Reactions for the Production of Energetic Materials" |
| 8:35 pm - 8:40 pm | Discussion |
| 8:40 pm - 9:20 pm | Henry Lee (University of New Haven, USA) "Lessons Learned from High Profile Cases" |
| 9:20 pm - 9:30 pm | Discussion |
| Friday | |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
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