| 성과번호 |
JNAL-MSI-2024-026623 |
성과년도 |
2024 |
| 논문명 |
Advancing high-throughput screening systems for synthetic biology and biofoundry |
| 저널/학술지 |
Current opinion in systems biology |
| ISSN번호 |
2452-3100 |
SCI구분 |
SCI |
| 저자 |
권길광, 이승구 |
| 키워드 |
한글 |
|
| 영문 |
|
| 초록 |
요약 |
High-throughput (HT) methodologies are extensively applied in synthetic biology for the rapid enrichment and selection of desired properties from a wide range of genetic diversity. In order to effecti... |
| 전체 |
High-throughput (HT) methodologies are extensively applied in synthetic biology for the rapid enrichment and selection of desired properties from a wide range of genetic diversity. In order to effectively analyze these vast variants, HT tools must offer parallel experiments and compact reaction capabilities to enhance overall throughput. Here, we discuss about various aspects of three representative high-throughputscreening (HTS) systems: microwell-, droplet-, and singlecell-based screening. These systems can be categorized based on their reaction volume, which in turn determines the associated technology, machinery, and supporting applications.Furthermore, HT techniques that rapidly connect numerous genotypes and phenotypes have evolved to enhance the precision of predictions through the integrationof digital technologies like machine learning and artificial intelligence. The use of advanced HT techniques within biofoundry will enable rapid selection and analysis from extensive genetic diversity, making it a driving force for the advancement of synthetic biology. |
| 국내외구분 |
국외 |
국내외학술지구분 |
국외전문학술지 |
| 연구수행주체 |
출연연구소 |
학술지구분 |
학술지 |
사업명
|
바이오.의료기술개발(R&D) |
부처명 |
과학기술정보통신부 |
| 과제고유번호 |
2710074687 |
과제년도 |
2024 |
| 과제명 |
설계-제작 플랫폼 구축을 통한 합성생물학 고도화 핵심기술 개발 |
| 6T분류 |
|
국가기술지도명 |
|
| 과학기술표준분류 |
달리 분류되지 않는 융합바이오(LA0799), 시스템생물학(LA0705), 효소공학(LA0804) |
