해외뉴스
(해외) 합성생물학 뉴스
해외뉴스
총 게시물 988건
| 988 | 기술 |
Mouse stem cell lines offer new window into autism's genetic associations
To study the genetic causes of autism spectrum disorder, a Kobe University research team has created a bank of 63 mouse embryonic stem cell lines containing the mutations most strongly associated with the disorder. The achievement was made possible by developing a new and more efficient method for changing the genome of embryonic stem cells. In the journal Cell Genomics, Takumi and his team have now published research showing that they were able to develop their cells into a broad range of cell types and tissues, and even generate adult mice with their genetic variations. The analysis of these alone proved that their cell lines were adequate models for studying autism spectrum disorder. However, the cell lines also allowed them to conduct large-scale data analyses to clearly identify genes that are abnormally active, and in which cell types this is the case.
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| 987 | 기술 |
Genome engineers expand the reach and precision of human gene editing
For the new study, the Yale team used a CRISPR-associated protein Cas12—which is similar to Cas9, a protein that can act as a sort of "molecular scissor" that can precisely cut or modify portions of DNA—and so-called guide RNAs (gRNAs). When fused to an enzyme, Cas9 and Cas12 can make targeted chemical changes to DNA at locations determined by the gRNA sequence. The team chose Cas12 because of its innate ability to process an RNA array containing many gRNAs. To improve the precision of editing, the team engineered the gRNAs by shortening the gRNA sequence or modifying the RNA bases. They then used the new system to successfully alter gene sequences with greater precision at 15 different sites in human cells—three times as many locations as had been previously engineered.
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| 986 | 기술 |
Bio-ARC by Fermbox Bio: A Full-Stack System for Lab-to-Launch Biomanufacturing
Bio-ARC brings together strain engineering, enzyme design, process development, and manufacturing into one adaptive system. It serves as a blueprint for moving biology from the lab bench to the production line. The name “Bio-ARC” reflects Fermbox Bio's mission to advance biology through new frontiers—a platform designed to translate biological ideas into large-scale applications and drive the shift toward a bio-based, low-carbon economy. Bio-ARC addresses this by collapsing those silos. By integrating strain and enzyme engineering with early-stage process insights, the platform builds a direct path from genetic design to manufacturable reality. It supports multiple microbial hosts—bacteria, yeast, and fungi—giving flexibility to match the right chassis to each product.
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| 985 | 기술 |
Stem cell platform aims to recreate brain's immune system using lab-grown human microglia cells
A research team at the Wyss Institute at Harvard University and Harvard Medical School (HMS) led by Wyss Founding Core Faculty member George Church, Ph.D. has devised a solution for creating microglia with strong functional similarities to human microglia from induced pluripotent stem cells (iPSCs) within four days, compared to 35 days it takes to obtain similar, yet less fine-tuned cells in a conventional differentiation process. Their approach builds on a previously developed technology known as TFomeTM that can be used to drive multiple cell differentiation processes in the dish more efficiently than other methods can. In TFomeTM technology, critical instructive proteins known as transcription factors (TFs) that orchestrate entire gene expression programs are expressed in iPSCs to specify their fate toward differentiated functional cell types.
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| 984 | 기술 |
CRISPR-based technology leads to discovery of complex multigenic traits in tomato plants
Researchers from Tel Aviv University have developed a genetic editing method tailored to crop plants, which has influenced various traits in tomato plants, including the taste and shape of the fruit. The researchers believe this innovative technology can be applied to a wide variety of crop species and may eventually be used to cultivate new and improved plant varieties. "In the current study, we significantly improved the method's efficiency, enabling us to examine the roles of thousands of genes. Secondly, many plants exhibit 'genetic redundancy': different genes from the same family, composed of similar amino acid sequences, compensate for one another and preserve the trait even if one gene is deactivated or edited."
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| 983 | 기술 |
Engineered oilseed crop produces high levels of powerful antioxidant
In a major step forward for sustainable pigment production, scientists have successfully engineered the oilseed crop Camelina sativa to produce high levels of astaxanthin—a valuable red antioxidant used to color farmed salmon and shrimp—using plant-derived genes rather than bacterial pathways. The findings, from a joint US/UK research team of biotechnologists led by Prof. Edgar Cahoon, director of the Center for Plant Science Innovation at the University of Nebraska-Lincoln (UNL), could offer a commercially viable alternative to synthetic astaxanthin, which is currently produced through costly chemical synthesis or from limited natural sources like algae.
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| 982 | 산업 |
Dutch firm EV Biotech introduces ArtemisAI for smarter microbial engineering
EV Biotech, a Dutch synthetic biology company, has announced the launch of ArtemisAI. This proprietary AI platform is set to transform how microbial strains are designed for industrial fermentation. ArtemisAI combines constraint-based modeling with machine learning. It creates a hybrid system that provides predictive and interpretable insights. Even with limited data, it helps make faster, smarter decisions in microbial engineering and media optimization. The platform allows developers to predict the best gene and regulatory targets using small datasets. It can simulate strain performance under different media and process conditions. It also helps prioritize edits that improve fermentation economics.
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| 981 | 기술 |
'In-insect synthesis': Caterpillar factories produce fluorescent nanocarbons
Researchers led by Kenichiro Itami at the RIKEN Pioneering Research Institute (PRI) / RIKEN Center for Sustainable Resource Science (CSRS) have successfully used insects as mini molecule-making factories, marking a breakthrough in chemical engineering. Referred to as "in-insect synthesis," this technique offers a new way to create and modify complex molecules, which will generate new opportunities for the discovery, development, and application of non-natural molecules, such as nanocarbons. Using techniques such as mass spectrometry, NMR, and X-ray crystallography, the researchers determined [6]MCPP-oxylene's structure. Experiments using molecular biology pinpointed two enzymes, CYP X2 and X3, as being responsible for the transformation.
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| 980 | 기술 |
First genetic 'toggle switch' for plants paves the way for smarter farming
Researchers at Colorado State University have developed a tool that can be used to switch a plant's key genetic traits on or off at will. The breakthrough was recently published in ACS Synthetic Biology and represents the first time that a synthetic genetic "toggle switch" has been used in a full-grown plant. Synthetic biologists design and build new segments of DNA that can then be inserted into living organisms to work like circuits in electronics or a computer. Just as a switch is used to turn a lightbulb on or off in an electric circuit, the team's "toggle" turns genes on and off when an external signal is applied. Up until now, the genetic toggle switch has only been used in single-celled organisms such as bacteria. The work at CSU is led by professors June Medford from the Department of Biology and Ashok Prasad from the Department of Chemical and Biological Engineering.
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| 979 | 산업 |
Integrated DNA Technologies Installs Custom Solutions Program to Accelerate Innovation in Synthetic Biology
With a continued focus on scaling its synthetic biology capabilities and offerings, global genomics leader Integrated DNA Technologies (IDT) established a synthetic biology customer solutions program, leveraging decades of manufacturing expertise to fuel research and development innovation. Powered by a dedicated team of scientists and synthetic biology experts, the program is designed to enable partnerships and agile collaboration with companies seeking custom-tailored solutions that extend beyond IDT’s catalog of synthetic biology offerings comprised of gene and gene fragments, and different vectors and plate formats for high-throughput workflows.
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