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(해외) 합성생물학 뉴스
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총 게시물 1124건
| 1124 | 기술 |
The genome editing playbook is different in neurons and other nondividing cells, researchers discover
A new study reveals that CRISPR-Cas9 gene editing works differently in non-dividing cells like neurons due to distinct DNA repair mechanisms, posing challenges for brain disorder therapies. Researchers found Cas9 persists longer and repair outcomes are limited but predictable in neurons. Crucially, they developed a novel strategy using nanoparticles to co-deliver CRISPR with molecules that inhibit specific DNA repair genes, allowing scientists to precisely control the DNA repair process after the cut, thereby improving the safety and efficacy of gene editing for neurons and other non-dividing cells like heart muscle cells.
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| 1123 | 기술 |
N새글
Single Prime Editing Platform Shows Potential vs. Multiple Diseases
Researchers developed PERT (Prime Editing-mediated Readthrough), a novel, disease-agnostic genome-editing strategy that offers a potential one-time treatment for multiple genetic diseases caused by nonsense mutations (premature termination codons). Instead of correcting every individual gene, PERT uses prime editing to permanently convert a dispensable endogenous tRNA into a highly efficient suppressor tRNA. This specialized tRNA ignores the premature stop signal, allowing the cell to produce full-length, functional proteins, regardless of which gene carries the mutation. PERT successfully restored protein function and alleviated symptoms in several disease models, demonstrating a strategy to overcome the logistical and financial bottlenecks associated with developing separate genetic medicines for rare diseases.
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| 1122 | 기술 |
Cancer Breakthrough: ‘Like an Arrow That Hits Only the Bullseye’
Researchers at ChristianaCare's Gene Editing Institute achieved a major breakthrough in cancer therapy by using CRISPR technology to disable the NRF2 gene in lung cancer cells. The NRF2 gene is a known driver of chemotherapy resistance. Disabling it restored the tumors' sensitivity to standard chemotherapy drugs (like carboplatin and paclitaxel) and slowed tumor growth in both cell lines and animal models. This precision approach is significant because disrupting NRF2 in only 20% to 40% of tumor cells was sufficient to improve outcomes, suggesting a viable strategy for making existing drugs effective again against not only lung cancer but potentially a wide range of NRF2-driven treatment-resistant solid tumors.
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| 1121 | 산업 |
N새글
Engineering the Future: How Gene Synthesis Companies Are Accelerating the Synthetic Biology Revolution
Gene synthesis companies are rapidly accelerating the Synthetic Biology Revolution by automating and standardizing DNA creation, making it fast, precise, and affordable. These firms serve as essential infrastructure, translating digital designs (often optimized by AI) into physical DNA, thus enabling researchers to design and test biological systems at unprecedented speed. This technological shift is driving global collaboration and fueling innovations across fields like agriculture and medicine.
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| 1120 | 기술 |
Next-generation microbiome medicine may transform Parkinson's treatment
The University of Georgia research team leveraged synthetic biology to solve the problem of fluctuating L-DOPA drug levels in Parkinson's disease treatment. The team genetically engineered a safe probiotic bacterium (E. coli Nissle 1917) into a "living medicine" that continuously produces and delivers Levodopa from the gut to the brain. This groundbreaking, non-invasive oral therapy platform promises to provide steady drug delivery, potentially reducing motor complications like dyskinesia and significantly improving the quality of life for Parkinson's patients.
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| 1119 | 기술 |
A Saliva Test Could Quickly Reveal Your Hidden Risk of Heart Failure
A new non-invasive saliva test has been developed to quickly screen for the risk of heart failure by measuring the level of S100A7 protein messenger RNA (mRNA). Levels of S100A7 protein are nearly double in heart failure patients compared to healthy individuals. The newly developed mRNA test, when analyzing patient saliva, showed an 82 percent accuracy in identifying heart failure patients, outperforming standard diagnostic assays (52 percent). This method offers a simple, accessible, and potentially early screening tool for a condition often diagnosed late due to subtle symptoms and inaccessible existing tests.
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| 1118 | 기술 |
Tailoring Agonists for Precise Notch Signaling Activation
Researchers led by D.H. Perez have introduced synthetic agonists engineered via synthetic biology and computational modeling to achieve precise and targeted activation of the Notch signaling pathway. Notch signaling is a crucial cell communication mechanism implicated in cancer and developmental disorders, but it has been difficult to modulate with natural ligands due to lack of specificity. The synthetic agonists overcome this limitation by selectively activating specific Notch receptors, allowing for tailored therapeutic interventions such as stimulating stem cell differentiation or inhibiting tumorigenesis. This innovation represents a paradigm shift in drug development, promising more reliable therapies with fewer side effects by providing a controllable means to target intricate cellular pathways.
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| 1117 | 기술 |
From Bark to Bench: Innovations in QS-21 Adjuvant Characterization and Manufacturing
This review examines the challenges in developing effective vaccine adjuvants, focusing on the potent saponin-based adjuvant QS-21. While highly effective in promoting both humoral and cellular immunity, QS-21's use is limited by hydrolytic instability, dose-limiting toxicity, and dependence on unsustainable natural sources (tree bark). The paper discusses strategies to improve its function (structural modification, nanoparticle formulation) and, crucially, highlights the promise of synthetic biology and bioengineering to achieve sustainable and scalable production of QS-21 and its analogs in microbial or plant platforms. The authors propose an integrated "bark to bench" development pipeline that leverages synthetic biology, AI, and systematic immune profiling to accelerate the discovery and deployment of next-generation adjuvants.
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| 1116 | 기술 |
Scientists Tricked Bacteria Into Making the Octopus’s Secret Camouflage Pigment
Scientists successfully used a synthetic biology approach called "growth-coupled biosynthesis" to engineer the bacterium Pseudomonas putida to mass-produce xanthommatin, the elusive color-shifting pigment found in octopuses and squids. The key innovation involved genetically redesigning the bacteria’s metabolic pathway so that the production of xanthommatin (and its byproduct, formic acid) became essential for the organism's growth and survival. This method dramatically increased the pigment yield to 1-3 grams per liter, roughly 1,000 times the prior rate. This breakthrough paves the way for the scalable, sustainable production of nature-inspired materials for applications in camouflage, smart materials, and cosmetics, and serves as a model for future biomanufacturing of complex molecules.
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| 1115 | 기술 |
A synthetic regeneration cascade for genetically editing crops
A research team has created gene-edited crops without using tissue culture. A team of plant biotechnologists led by Gunvant Patil at Texas Tech University (TX, USA) has developed a groundbreaking method that could dramatically speed up the development of gene-edited crops. The method would allow scientists to bypass one of the most time-consuming and technically challenging steps in plant biotechnology – tissue culture. By combining two powerful genes – WIND1, which triggers cells near a wound to reprogram themselves, and the isopentenyl transferase (IPT) gene, which produces natural plant hormones promoting new shoot growth – the team created a self-contained regeneration cascade. This system successfully generated gene-edited shoots in multiple crops, including tobacco, tomatoes and soybeans.
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