합성생물학 역사

합성생물학 역사

합성생물학 역사

A brief history of
synthetic biology

- Timeline -

출처
Nature Reviews Microbiology 12(5), 381-390 (2014)

The second decade of synthetic biology_2010-2020

2010년 이후

2019
  • Full synthesis of E. coli genome
  • Carbon fixation in engineered E. coli
  • Gene circuits with designed proteins
  • Synthetic production of cannabinoids
2018
  • CAR-T cells with logic control
  • Yeast with synthetically fused chromosomes
  • Self-organizing multicellular structures
2017
  • Synthesis of 5 more yeast chromosomes
  • CRlSPR-based rapid diagnostics
2016
  • In vivo event recorders
  • Synthesis of a reduced mycoplasma genome
  • Cello CAD for E. coli logic gates
2015
  • E. coli dependent on synthetic amino acids/li>
  • Biosynthesis of opioids from yeast
2014
  • Bacteria that sense and record in the gut Cell-free paper-based sensors and logic
  • E. coli engineered with 6 bases of DNA
  • Synthesis of a yeast chromosome
2013
  • Biosynthetic production of artemisinin
  • Genomically recoded E. coli
2012
  • DNA used for data storage
  • Refactored nitrogen fixation cluster
  • Whole cell simulation of a mycoplasma
2011
  • Phage-based continuous evolution
  • Bacterial growth in stripe patterns
2010
  • Synchronized bacterial oscillators
  • Synthetic mycoplasma genome
Key to coloured boxes
black
technical or cultural milestones
green
synthetic biology in metabolic engineering
blue
therapeutic applications
red
circuit engineering
puple
whole genome engineering
Acronym
E. coli
Escherichia coli
iGEM
International Genetically Engineered Machine
MAGE
multiplex automated genome engineering
SB1.0.
Synthetic Biology 1.0
MIT
Massachusetts Institute of Technology
S. cerevisiae
Saccharomyces cerevisiae