합성생물학 역사
합성생물학 역사
합성생물학 역사
A brief history of
synthetic biology
synthetic biology
- Timeline -
- 출처
- Nature Reviews Microbiology 12(5), 381-390 (2014)
2005년 이전
- 1960s
-
- Cellular regulation by molecular networks postulated by Jacob and Monod
- 1970s
-
- (1970s-1980s)
Development of molecular cloning techniques
- (1970s-1980s)
- 1980s
-
- (1980s-1990s)
Rise of 'omics' era of high-throughput biology
- (1980s-1990s)
- 1990s
-
- Widespread use of automated DNA sequencing
- Complete genome sequence of S.cerevisiae
- Complete genome sequence of E.coli
- 2000
-
- First synthetic circuits-toggle switch and repressilator
- Autoregulatory negative-feedback circuit
- 2001
-
- First cell-cell communication circuit based on quorum sensing
- 2002
-
- Earliest combinatorial synthesis of genetic networks
- (2002-2003)
Synthetic circuits used to study transcriptional noise during this period
- 2003
-
- Artemisinin precursor pathway engineered in E. coli
- 2004
-
- SB1.0: the first international conference for synthetic biology held at MIT
- First iGEM competition held at MIT
- RNA devices for modular regulation of gene expression
- 2005
-
- Light-sensing circuit engineered inE. coli-bacterial photography
- Programmable ligand-controlled transcript regulation by RNA
- Circuits capable of multicellular pattern formation are generated
2006 ~ 현재
- 2006
-
- Bacteria engineered
to invade cancer
cells
- Bacteria engineered
- 2007
-
- Engineered
bacteriophage for
biofilm dispersal
- Engineered
- 2008
-
- RNA devices for
performing logical
operations - Construction of
a robust
and stable relaxation oscillator - Biofuel production
using amino
acid metabolism
in E. coli
- RNA devices for
- 2009
-
- Gibson DNA assembly described
- MAGE described
- Engineering of
an eventcounting circuit - Engineering of
an edgedetector circuit
- 2010
-
- Programmable
microbial kill switch - Creation of a bacterial
cell with
a synthetic genome - Synchronized genetic
clock for
population-coupled
oscillatory waves
- Programmable
- 2011
-
- Complete set of
Boolean logic gates
reported for E. coli - Engineering of
synthetic yeast
chromosome arms
- Complete set of
- 2012
-
- Multiple input logic
cascade described - Dynamic control of
metabolic flux
for biodiesel
production
- Multiple input logic
- 2013
-
- Commercial
production of
artemisinin by Amyris
using engineered
yeast strain
- Commercial
Key to coloured boxes
- black
- technical or cultural milestones
- green
- synthetic biology in metabolic engineering
- blue
- therapeutic applications
- red
- circuit engineering
- puple
- whole genome engineering
Acronym
- E. coli
- Escherichia coli
- iGEM
- International Genetically Engineered Machine
- MAGE
- multiplex automated genome engineering
- SB1.0.
- Synthetic Biology 1.0
- MIT
- Massachusetts Institute of Technology
- S. cerevisiae
- Saccharomyces cerevisiae