합성생물학 역사

합성생물학 역사

합성생물학 역사

A brief history of
synthetic biology

- Timeline -

출처
Nature Reviews Microbiology 12(5), 381-390 (2014)

2005년 이전

1960s
  • Cellular regulation by molecular networks postulated by Jacob and Monod
1970s
  • (1970s-1980s)
    Development of molecular cloning techniques
1980s
  • (1980s-1990s)
    Rise of 'omics' era of high-throughput biology
1990s
  • Widespread use of automated DNA sequencing
  • Complete genome sequence of S.cerevisiae
  • Complete genome sequence of E.coli
2000
  • First synthetic circuits-toggle switch and repressilator
  • Autoregulatory negative-feedback circuit
2001
  • First cell-cell communication circuit based on quorum sensing
2002
  • Earliest combinatorial synthesis of genetic networks
  • (2002-2003)
    Synthetic circuits used to study transcriptional noise during this period
2003
  • Artemisinin precursor pathway engineered in E. coli
2004
  • SB1.0: the first international conference for synthetic biology held at MIT
  • First iGEM competition held at MIT
  • RNA devices for modular regulation of gene expression
2005
  • Light-sensing circuit engineered inE. coli-bacterial photography
  • Programmable ligand-controlled transcript regulation by RNA
  • Circuits capable of multicellular pattern formation are generated

2006 ~ 현재

2006
  • Bacteria engineered
    to invade cancer
    cells
2007
  • Engineered
    bacteriophage for
    biofilm dispersal
2008
  • RNA devices for
    performing logical
    operations
  • Construction of
    a robust
    and stable relaxation oscillator
  • Biofuel production
    using amino
    acid metabolism
    in E. coli
2009
  • Gibson DNA assembly described
  • MAGE described
  • Engineering of
    an eventcounting circuit
  • Engineering of
    an edgedetector circuit
2010
  • Programmable
    microbial kill switch
  • Creation of a bacterial
    cell with
    a synthetic genome
  • Synchronized genetic
    clock for
    population-coupled
    oscillatory waves
2011
  • Complete set of
    Boolean logic gates
    reported for E. coli
  • Engineering of
    synthetic yeast
    chromosome arms
2012
  • Multiple input logic
    cascade described
  • Dynamic control of
    metabolic flux
    for biodiesel
    production
2013
  • Commercial
    production of
    artemisinin by Amyris
    using engineered
    yeast strain
Key to coloured boxes
black
technical or cultural milestones
green
synthetic biology in metabolic engineering
blue
therapeutic applications
red
circuit engineering
puple
whole genome engineering
Acronym
E. coli
Escherichia coli
iGEM
International Genetically Engineered Machine
MAGE
multiplex automated genome engineering
SB1.0.
Synthetic Biology 1.0
MIT
Massachusetts Institute of Technology
S. cerevisiae
Saccharomyces cerevisiae