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| 949 | 기술 |
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Novel Biosensors Offer In Vivo RNA Imaging in Plants
Traditional methods for studying RNA dynamics in plants rely on destructive sampling, capturing only static snapshots of gene activity, making it difficult to track RNA signals in real time. To address this challenge, researchers at Oak Ridge National Laboratory developed a split ribozyme-based biosensor that enables in vivo detection of RNA signals by converting them into a measurable protein output. This biosensor allows scientists to observe gene expression as it happens, without requiring invasive and destructive techniques. This technology functions by utilizing a split ribozyme mechanism that activates in the presence of a target RNA, triggering the reassembly of a fluorescent protein, such as superfolder GFP (sfGFP). Successfully tested in Nicotiana benthamiana and Arabidopsis thaliana, the biosensor demonstrated its ability to track both native plant RNA and foreign RNA, making it a versatile tool for plant biology and biotechnology.
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| 948 | 기술 |
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3D printed hydrogels guide cell growth to form functional tissue structures
Researchers at the Terasaki Institute for Biomedical Innovation (TIBI) have developed a technique that could help advance treatments in tissue engineering. The study, published in the journal Small, introduces a technique for producing tissues with precise cellular organization designed to mimic the natural structure of human tissue. Using a simple light-based 3D printing method, the team created microgels with controlled internal architectures. These structures help guide how cells behave and grow, mimicking the way cells naturally behave in the body.
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| 947 | 기술 |
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Designing enzymes from scratch: New workflow paves way for more powerful and environmentally benign chemistry
Researchers at UC Santa Barbara, UCSF and the University of Pittsburgh have developed a new workflow for designing enzymes from scratch, paving the way toward more efficient, powerful and environmentally benign chemistry. The new method allows designers to combine a variety of desirable properties into new-to-nature catalysts for an array of applications, from drug development to materials design. Using the helical bundle protein as a framework, the team used state-of-the-art artificial intelligence methods to design sequences of amino acids that underlie the protein structures with the desired functionalities and properties to turn the bundle into an enzyme.
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| 946 | 기술 |
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Biosensor uses pH-responsive DNA nanoswitches for highly sensitive bladder cancer detection in urine
A study published in ACS Nano presents a novel biosensor for the isothermal, highly sensitive detection of bladder cancer biomarkers—miRNAs, short non-coding RNAs that regulate gene expression—using programmable pH-responsive triplex DNA nanostructures. The platform employs triplex DNA nanoswitches (TDNs) designed to respond to specific pH conditions. Two TDNs were engineered to target miR-183 and miR-155, which are overexpressed in bladder cancer.
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| 945 | 기술 |
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Engineered Vibrio natriegens strain boosts bioremediation of complex pollutants in harsh environments
A multi-institutional collaboration of synthetic biology research centers in China has developed a genetically engineered strain of Vibrio natriegens capable of bioremediating complex organic pollutants, including biphenyl, phenol, naphthalene, dibenzofuran, and toluene, in saline wastewater and soils. Synthetic degradation gene clusters targeting biphenyl, phenol, naphthalene, dibenzofuran, and toluene were chemically synthesized and assembled in yeast. Gene clusters were subsequently integrated into the Vibrio natriegens Vmax genome and verified through PCR analysis and sequencing to confirm genetic stability and correct orientation.
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| 944 | 기술 |
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Enzymatic and genetic advances streamline synthesis of promising natural products
A team headed by HIPS department head Tobias Gulder has now developed new synthetic strategies for the class of polycyclic tetramate macrolactams (PoTeMs), a group of natural products with a broad spectrum of biological activities. In addition to chemical synthesis, enzymatic catalysis and genetic engineering approaches were used. The strategies established in this way not only allow PoTeMs to be produced in large quantities, but also to modify their carbon structure and thus their pharmaceutical properties. The researchers published their results in the journals Biotechnology and Bioengineering, Microbial Cell Factories and Angewandte Chemie International Edition.
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| 943 | 기술 |
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Catalan researchers create "new switches" to control anything with AI
"We have taken a very important step towards understanding the language of DNA." With this statement, Lars Velten, a researcher at the Center for Genomic Regulation (CRG), tried to quantify the extent to which the results of the study his team published this Thursday in the journal CellThe research group from the CRG and EMBL-Barcelona has succeeded in creating an artificial intelligence (AI) tool capable of designing regulatory DNA sequences never seen in nature. "We can say that we have created new switches [enhancers] that until now did not exist in the mammalian genome and that in the future could be used to control whether a gene is turned on or not in a specific cell," explains Velten, lead author of the research.
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| 942 | 기술 |
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AI-designed DNA controls genes in healthy mammalian cells for first time
A study published today in the journal Cell marks the first reported instance of generative AI designing synthetic molecules that can successfully control gene expression in healthy mammalian cells. Researchers at the Centre for Genomic Regulation (CRG) created an AI tool which dreams up DNA regulatory sequences not seen before in nature. The model can be told to create synthetic fragments of DNA with custom criteria, for example: 'switch this gene on in stem cells which will turn into red-blood-cells but not platelets.' The model then predicts which combination of DNA letters (A, T, C, G) are needed for the gene expression patterns required in specific types of cells. Researchers can then chemically synthesise the roughly 250-letter DNA fragments and add them to a virus for delivery into cells.
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| 941 | 기술 |
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AI model provides clues about how a virus may evolve and the immune response it could provoke
The new model, described May 8 in the journal Immunity, uses evolutionary, biological, and structural information about a virus to predict and design surface proteins likely to occur as the pathogen mutates. The researchers successfully applied EVE-Vax to SARS-CoV-2, designing viral proteins that elicited similar immune responses as the actual proteins that evolved during the COVID-19 pandemic. The research suggests that the model provides valuable information about the future evolution of a virus and can be used to create panels of "designer" proteins to evaluate the future protection of vaccines. The researchers hope that the model will eventually help scientists develop better vaccines to combat viral outbreaks and pandemics caused by rapidly mutating viruses.
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| 940 | 기술 |
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In vivo 3D printing using sound holds promise for precise drug delivery, wound healing and more
A team of scientists led by Caltech has taken a significant step toward that ultimate goal, having developed a method for 3D-printing polymers at specific locations deep within living animals. The technique relies on sound for localization and has already been used to print polymer capsules for selective drug delivery as well as glue-like polymers to seal internal wounds. They came up with a novel approach: Combine ultrasound with low-temperature–sensitive liposomes. Such liposomes, spherical cell-like vesicles with protective fat layers, are often used for drug delivery.
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