해외뉴스
(해외) 합성생물학 뉴스
해외뉴스
총 게시물 1023건
| 973 | 기술 |
3D genome mapping technology sheds light on how plants regulate photosynthesis
Chinese researchers have developed a technology that sheds light on how the three-dimensional (3D) organization of plant genomes influences gene expression—especially in photosynthesis. The research, which was led by Prof. Xiao Jun at the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences, in collaboration with BGI Research, is published in Science Advances. The innovative method not only provides a more precise tool for understanding the intricate 3D interactions between genes, but also highlights the critical role of long-range chromatin interactions in gene regulation.
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| 972 | 기술 |
Artificial cell-like structures mimic self-reproduction and release polymeric spores
The researchers designed a non-biochemical system in which synthetic cell-like structures form and self-reproduce by ejecting polymeric spores. The PNAS paper reports a one-pot reaction in which chemically active polymer protocells began their journey as a uniform mixture of molecules that usually do not self-assemble. However, when placed under green light (530 nm), they formed vesicle-like structures that grew and divided as the reaction proceeded. They observed that the mixture of chemicals undergoes photo-Reversible Addition-Fragmentation Chain Transfer (RAFT) photopolymerization in water to transform the starting molecules into amphiphilic block copolymers. These block copolymers then gave rise to non-biochemical polymer vesicles or synthetic cells that displayed self-reproduction behavior via PISA.
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| 971 | 산업 |
Telesis Bio Announces Licensing Agreement with Regeneron to Adopt Gibson SOLA™ Platform for Rapid On-Site DNA and Gene Synthesis
SAN DIEGO--(BUSINESS WIRE)--Telesis Bio Inc. (OTCMKTS: TBIO), a leading provider of DNA and mRNA synthesis solutions to accelerate therapeutic discovery with fast and flexible on-site automated foundries, today announced a new license agreement with Regeneron Pharmaceuticals, Inc. to deploy Telesis Bio’s revolutionary Gibson SOLA™ platform at its R&D core facilities. This will help Regeneron adopt automated, high-throughput, on-demand gene synthesis in their own labs. This agreement reflects a broader industry shift toward gaining a competitive edge that comes with internalizing synthetic biology capabilities to increase velocity, enhance data security, and drive AI-powered drug discovery. Telesis Bio’s Gibson SOLA platform addresses these needs by allowing scientists to perform long, complex nucleic acid synthesis using standard laboratory automation—eliminating the delays and limitations of traditional methods.
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| 970 | 기술 |
Strand Therapeutics Announces Initial First-in-human Phase 1 Data for STX-001 in Patients with Advanced Solid Tumors at The 2025 ASCO Annual Meeting
Strand Therapeutics, a leader in next-generation mRNA-based therapeutics, today announced exciting preliminary Phase 1 clinical data for its lead investigational candidate, STX-001, in patients with advanced solid tumors. The study marks the first clinical evidence of Strand’s proprietary programmable mRNA technology platform and represents a major milestone in the company’s mission to bring next-generation mRNA therapies to patients with cancer. STX-001 encodes IL-12, an immunomodulatory protein, which the company has designed such that it can reprogram the tumor microenvironment and stimulate a systemic anti-tumor immune response. Unlike traditional mRNA therapies, Strand’s approach uses self-replicating mRNA, ensuring localized and durable therapeutic activity.
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| 969 | 기술 |
Scientists Discover Bizarre Bacteria That “Breathe” Electricity Instead of Air
A team led by Rice University bioscientist Caroline Ajo-Franklin has discovered how certain bacteria breathe by generating electricity, using a natural process that pushes electrons into their surroundings instead of breathing oxygen. The findings, published in Cell, could enable new developments in clean energy and industrial biotechnology. The researchers found that some bacteria use naturally occurring compounds called naphthoquinones to transfer electrons to external surfaces. This process, known as extracellular respiration, mimics how batteries discharge electric current, enabling bacteria to thrive without oxygen. The technology may also enable bioelectronic sensors in oxygen-deprived environments, offering new tools for medical diagnostics, pollution monitoring, and deep-space exploration.
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| 968 | 기술 |
Gene editing disrupts Huntington's mutation in mice
The Broad team has developed a new approach to prevent these DNA repeats from expanding. Using a technique called base editing, the team introduced single-letter changes into the middle of the repeated stretch of DNA, interrupting the sequence in patient cells and mouse models of Huntington's disease and Friedreich's ataxia. They found that the edited DNA tracts stayed the same in length or even became shorter over time. To shuttle the base editors to specific cells in mice, the researchers packaged them into dual AAV9 vectors, an adeno-associated virus designed to deliver cargo to neurons. The base editors stabilized the repeat tracts in mouse models of Friedreich's ataxia and Huntington's disease. In the meantime, the researchers are also developing a different approach using prime editing to replace disease-causing repeat tracts with a shorter, stable number of repeats all at once.
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| 967 | 기술 |
Flowers unfold with surprising precision, despite unruly genes
Flowers grow stems, leaves and petals in a perfect pattern again and again. A new Cornell study shows that even in this precise, patterned formation in plants, gene activity inside individual cells is far more chaotic than it appears from the outside. This finding has important implications for plant engineering, where scientists design artificial gene switches to control growth or behavior. Understanding how plants manage genetic "noise" could also inform research in other fields, from synthetic biology, where predictability is crucial, to research on cancer, where random gene activity can drive tumor evolution. The researchers examined thale cress (Arabidopsis thaliana), a small plant in the mustard family, to look at stochastic gene expression—the process through which genes can randomly turn on or off. The team found that genes responding to auxin—a hormone that directs flower growth—were activated in a surprisingly random way from cell to cell, even when the hormone signal was the same.
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| 966 | 기술 |
Novel gene therapy tools target inherited retinal degenerations at advanced stages
Led by Penn Vet's Raghavi Sudharsan, an assistant professor of experimental ophthalmology, and William A. Beltran, the Corinne R. Henry Bower Endowed Professor of Ophthalmology, the team developed four novel photoreceptor-specific promoters. "These short segments of DNA act as molecular 'switches' to turn on the therapeutic gene in target cells, driving strong and specific gene expression in rod and cone photoreceptors even in mid-to-late stages of disease," explains Sudharsan, the lead author on the paper. "This study addresses one of the biggest hurdles in IRD treatment: how to deliver effective gene therapy after a large portion of the retina has already degenerated," says Sudharsan.
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| 965 | 기술 |
Discovering new ways to recharge T-cells fighting cancer
"In cancer, in addition to inhibitory receptors, activated T-cells also exhibit upregulation of numerous co-stimulatory receptors like 4-1BB," said Zhang, who was senior author of the study. "There's a longstanding research interest in agonizing these co-stimulatory pathways." In the study, scientists first triggered the 4-1BB signaling to boost T-cell activity. They found that the increased survival and expansion of T-cells with 4-1BB stimulation required two key metabolic molecules needed to regulate oxidative stress, GSH and GPX4, but were more susceptible to exhaustion over time. Next, scientists genetically deleted A2BR in mice—a receptor that suppresses immune responses causing exhaustion—while also being regulated by 4-1BB signaling. They found that levels of GSH and GPX4 stabilized and exhaustion decreased without A2BR upon 4-1BB stimulation.
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| 964 | 기술 |
Engineered bacteria can deliver antiviral therapies and vaccines
New research from the University of Cincinnati demonstrates how specially engineered bacteria taken orally can operate as a delivery system for antiviral therapies and vaccines. Nitin S. Kamble, Ph.D., a research scientist in Kotagiri's lab, systematically screened anchor motifs and expression cassettes to optimize antigen density on the probiotic surface. For the vaccine version, the bacteria was designed to express the spike protein found on the surface of the virus that causes COVID-19. This same spike protein is currently delivered through mRNA COVID-19 vaccines.
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