해외뉴스
(해외) 합성생물학 뉴스
해외뉴스
총 게시물 1019건
| 919 | 기술 |
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Scientists repurpose gene editing tool to help uncover hidden microbial diversity
Pioneering research led by the University of Bristol has repurposed a gene-editing tool to help shed light on the true biodiversity present in natural environments. The team of biologists overcame this issue by repurposing CRISPR—a revolutionary gene-editing tool—to gain a fuller picture, using it to extract long DNA "barcodes" that could more accurately identify the microbes present within a sample. Nikolaeva-Reynolds explained, "By capturing long DNA signatures that are unique to each type of microbe and reading these using DNA sequencing, we can provide a clearer picture of the communities present, giving biologists a more complete picture of these intricate microbial worlds."
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| 918 | 기술 |
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Live imaging reveals how viruses spread through the gut microbiome
Researchers at the University of California, Irvine have developed a live-imaging system, Phollow, that tracks individual bacteriophages as they spread through the gut of zebrafish, showing that phages from different bacterial hosts vary in how they replicate, disseminate, and interact with host tissues. Phollow was applied in germ-free zebrafish colonized with engineered strains of E. coli and Plesiomonas, allowing visualization of phage behavior at single-virion resolution. Researchers constructed fluorescently tagged phages and introduced them into modified bacterial hosts referred to as Phollow virocells.
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| 917 | 기술 |
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Researchers use machine learning to engineer ‘bespoke enzymes’ for gene editing
Genome editing has advanced at a rapid pace with promising results for treating genetic conditions—but there is always room for improvement. A new paper by investigators from Mass General Brigham published in Nature showcases the power of scalable protein engineering combined with machine learning to boost progress in the field of gene and cell therapy. In their study, authors developed a machine learning algorithm—known as PAMmla—that can predict the properties of about 64 million genome editing enzymes. The work could help reduce off-target effects and improve editing safety, enhance editing efficiency, and enable researchers to predict customized enzymes for new therapeutic targets. The newly published study aims to improve this by using machine learning to better predict and tailor enzymes to hit their targets with greater specificity. The approach also offers a scalable solution—other attempts at engineering enzymes have had a lower throughput and typically yielded orders of magnitude fewer enzymes.
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| 916 | 기술 |
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Gene syntax shown to control variability in synthetic plasmids
Engineers and biologists at Dartmouth College have found that, just like word order affects meaning in a sentence, the placement of genes within a plasmid—known as gene syntax—can influence how strongly each gene is expressed, how consistently it behaves across cells, and how it interacts with nearby genes. Results show that gene syntax is not a neutral feature of plasmid design. Orientation and order of genes within a plasmid influenced expression strength, relative ratios between genes, and expression variability. Changes in syntax affected not only isolated gene behavior but also the function of complex genetic circuits.
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| 915 | 기술 |
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Machine learning model to predict the fitness of AAV capsids for gene therapy
A new study in Human Gene Therapy describes a machine learning (ML) model that can be used as a surrogate for laborious in vitro experiments. This in silico approach aims to increase the fitness of clinical adeno-associated virus (AAV) capsids to make gene therapies more economically viable for patients. "By combining a protein language model (PLM) and classical ML techniques, our model achieved a significantly high prediction accuracy (Pearson correlation = 0.818) for capsid fitness," stated the investigators. "Importantly, tests on completely independent datasets showed robustness and generalizability of our model, even for multi-mutant AAV capsids."
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| 914 | 산업 |
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North Korea continues to pursue covert biological weapons program: US report
TAIPEI, Taiwan – North Korea continues to maintain a covert biological weapons program in violation of international treaties, according to a newly released U.S. government report. According to the report, the regime possesses “the technical capability to produce bacteria, viruses, and toxins that could be used as BW [biological weapons] agents” and is also capable of genetically engineering biological materials. “Pyongyang probably is capable of weaponizing BW agents with unconventional systems such as sprayers and poison pen injection devices, which have been deployed by the DPRK for delivery of chemical weapons and could be used to covertly deliver BW agents,” the report said.
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| 913 | 기술 |
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Uranium Extraction Goes Bio: The Rise of Protein Miners
With land-based uranium supplies dwindling, scientists are turning to the sea. Now, a breakthrough from China’s Hainan University may have cracked the code for extracting this critical fuel from seawater—thanks to a genetically engineered protein that binds uranium like a magnet. A team of researchers at Hainan University has engineered a novel protein, dubbed LSUBP, that could revolutionize how we harvest uranium from the ocean. Designed with precision genetic tweaks, LSUBP contains two uranyl-binding sites that dramatically improve the protein’s ability to adsorb uranium—making it one of the most effective materials ever developed for this purpose.
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| 912 | 기술 |
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Bacteria-Based Technology Could Revolutionize Solid Tumor Treatment
Neobe is tackling one of the biggest challenges in oncology – making existing cancer drugs more effective in treating solid tumors. Despite the numerous biological treatments available, many of these drugs fail to deliver their potential due to the dense, fibrotic nature of solid tumors, which blocks drug delivery and immune cell infiltration. Their innovative approach utilizes synthetic biology to engineer bacteria capable of breaking down the barriers within tumors, enabling better drug penetration and immune system activation. We’ve designed the entire technology with clinical translation in mind, ensuring both safety and efficacy. The proof, as they say, is in the pudding. We’re moving quickly toward our first human clinical trials and we’re actively fundraising to make that a reality. Our goal is to begin phase one trials in 2027. Once we have that data, we believe we’ll see exponential growth.
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| 911 | 기술 |
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Bird Flu Vaccine Gets Boost From Nanoparticle Tech
Jonathan Lovell, PhD, professor in the Department of Biomedical Engineering at UB, led the study focused on combating the 2.3.4.4b variant of H5N1. This particular strain has caused severe outbreaks in wild birds, poultry, and has even infected mammals such as cats, cattle, and sea lions. Lovell’s team developed an innovative approach by creating a vaccine that stimulates immune responses against two key viral proteins—hemagglutinin (H5) and neuraminidase (N1). At the core of Lovell’s approach is an innovative nanoparticle platform named CoPoP, consisting of cobalt and porphyrin nanoparticles coated with a phospholipid shell. This vaccine platform, known as a recombinant protein vaccine, utilizes tiny spherical nanoparticles engineered to display specific viral proteins to the immune system.
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| 910 | 산업 |
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The Increasing Value Of The Synthetic Biology Market By 2035
The Global Synthetic Biology Market is valued at USD 16.94 Billion in 2024 and is projected to reach a value of USD 167.98 Billion by 2035 at a CAGR (Compound Annual Growth Rate) of 23.20% between 2025 and 2035. Healthcare is the largest segment of the synthetic biology market, accounting for over 50% of the total market share. Within healthcare, synthetic biology is being used to develop new drugs, vaccines, and diagnostic tools, as well as to improve the production of existing pharmaceuticals. North America is the largest market for synthetic biology, followed by Europe and Asia-Pacific. The presence of a large number of biotech and pharmaceutical companies, as well as academic research institutions, in these regions has contributed to the growth of the synthetic biology market.
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