해외뉴스
(해외) 합성생물학 뉴스
해외뉴스
총 게시물 1020건
| 1020 | 기술 |
N새글
Data mining uncovers treasure-trove of previously 'untouchable' proteins for drug development
A new Science study expands the range of druggable targets using molecular glue degraders, which can now bind to a broader set of protein surface motifs beyond the previously limited beta-hairpin loop. These degraders manipulate cereblon (CRBN) to tag disease-related proteins for degradation via the ubiquitin-proteasome pathway. This approach opens new therapeutic avenues for previously "undruggable" proteins, including VAV1, which is linked to autoimmune and chronic inflammatory diseases.
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| 1019 | 기술 |
Gene-editing platform could boost anti-cancer immune responses
Researchers developed a gene-editing platform that enables T cells to release anti-cancer compounds only within tumors. This minimizes harmful side effects and boosts the effectiveness of immunotherapy against solid tumors. The breakthrough could lead to safer, more effective treatments for cancers like sarcomas and carcinomas.
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| 1018 | 산업 |
FDA-approved drugs can help enhance the safety of nanomedicines
Researchers found that repurposing FDA-approved drugs like iptacopan can reduce harmful immune responses to nanoparticles in nanomedicine.
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| 1017 | 산업 |
Designer Microbes: Can Synthetic Biology Supercharge Wastewater Treatment?
Synthetic biology offers promising solutions for pollution remediation by engineering microbes to degrade complex contaminants such as heavy metals, hydrocarbons, and pharmaceuticals. Tools like CRISPR and synthetic microbial consortia enhance pollutant breakdown efficiency and enable precise environmental sensing. However, real-world application remains limited due to ecological concerns, environmental variability, and high implementation costs.
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| 1016 | 기술 |
Evolving Deaminase Hotspots for Precise Cytosine Editing
The researchers directed evolution of the TadA enzyme to redesign it to precisely edit cytosines at specific sequences. This solved the non-selectivity of existing base editors and greatly improved their accuracy and safety. The newly developed 16 enzymes are precision genome editing tools that can be utilized in a variety of base environments.
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| 1015 | 기술 |
New method removes mysterious organelles from stem cells and embryos to reveal their roles
Researchers at UT Southwestern developed a genetic technique called "enforced mitophagy" to eliminate mitochondria from cells, revealing their essential roles in energy production and gene regulation.
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| 1014 | 기술 |
Aligned stem cell sheets boost protein production for improved tissue repair
Scientists developed a temperature-responsive striped culture surface that aligns mesenchymal stem cells into sheets, significantly enhancing their secretion of healing cytokines.
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| 1013 | 기술 |
Innovative nanocomposite hydrogel shows promise for cartilage regeneration in osteoarthritis treatment
Researchers from Northwest University, China, have developed a dual-drug-loaded nano-composite hydrogel to treat osteoarthritis by simultaneously reducing inflammation and promoting cartilage regeneration. The hydrogel delivers dexamethasone and kartogenin in a controlled, spatiotemporal manner, mimicking natural healing processes. In animal models, the hydrogel significantly improved cartilage repair and reduced inflammatory markers, showing promise for clinical applications in joint and musculoskeletal injuries.
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| 1012 | 기술 |
Self-driving lab: AI and automated biology combine to improve enzymes
Researchers at the University of Illinois developed a platform combining AI, robotics, and synthetic biology to improve enzyme functions efficiently.
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| 1011 | 기술 |
Jawbone organoids from patient iPS cells model bone disease and therapy development
Associate Professor Makoto Ikeya's team at Osaka University has developed jawbone-like organoids from iPS cells, providing a new model for studying jawbone development and disease. By inducing cranial neural crest cells into mandibular ectomesenchyme and culturing them in osteo-inductive conditions, the team generated mineralized, vascularized bone tissue both in vitro and in vivo. The organoids modeled osteogenesis imperfecta (OI) pathology and were corrected through gene editing, demonstrating the organoids' potential in disease modeling and regenerative medicine.
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