This study explores the development of biofoundries, emphasizing the integration of synthetic biology with artificial intelligence (AI) and robotics. It outlines critical challenges such as the necessity for interdisciplinary collaboration and the development of hardware, software, and AI specific to biofoundry operations. To address these challenges, we recommend strategies like rapid prototyping, soft integration, and the strategic implementation of AI. We underscore the vital role of synthetic biology researchers in advancing biofoundry capabilities and advocate for collaborative, multidisciplinary efforts to optimize the development and functionality of biofoundries.