Biosensing technologies have been used for decades in healthcare for such things as finger-stick glucose monitoring strips in the 1960s to urine-based pregnancy tests to wearable glucose monitors. All of these were revolutionary in their own right and improved patient care and awareness with each advancement. The next chapter in this story is being written now with breakthroughs in synthetic nucleic acid-based biosensors for precision diagnostics.

Nucleic acid-based biosensing is based on the intricate, specific molecular recognition process between nucleic acid (i.e., DNA or RNA) molecules and the desired molecular targets. Similar to proteins such as antibodies, DNA and RNA both possess the ability to specifically bind molecules of interest in complex biological fluids such as blood. This inherent trait forms the foundation for designing biosensors capable of detecting a wide range of analytes.

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[Med Device Online, 2023.9.13, https://www.meddeviceonline.com/doc/biosensing-technology-where-is-the-field-headed-0001]