Synthetic biologists in the laboratory of Rice bioengineer Jeff Tabor are preparing to shine a lot of light on B. subtilis' stressed-out decision making. Tabor's group has spent more than a decade developing optogenetic tools to turn bacterial genes on and off with light. A new $1.3 million grant from the National Science Foundation will allow Tabor's team to use its tools in collaboration with the lab of computational bioengineer Oleg Igoshin to decode B. subtilis' genetic response to stress.
"Bacteria are the product of billions of years of evolution, and as a result they are programmed to survive," said Tabor, the grant's principal investigator and an associate professor of bioengineering. "They respond to stress in complex ways that have health and economic implications. Decoding how they respond could lead to new technological advances in synthetic biology and even to sorely needed antimicrobial drugs."

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news-medical, 22.05.23
https://www.news-medical.net/news/20220523/Synthetic-biologists-interrogate-single-celled-survivalists-to-understand-stress-response.aspx